S6448
SYK、活性型、GSTタグ融合 ヒト
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
製品名
SYK、活性型、GSTタグ融合 ヒト, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
recombinant
expressed in baculovirus infected Sf9 cells
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
79-107 nmol/min·mg
mol wt
~100 kDa
UniProt accession no.
relevant disease(s)
cancer
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... SYK(6850)
Biochem/physiol Actions
SYKは、造血系細胞に広範に発現する非受容体型プロテインチロシンキナーゼです。活性化された免疫レセプターを下流のシグナリング事象と結び付ける働きをしており、このシグナル伝達が増殖、分化、貪食など様々な細胞応答を仲介しています。B細胞では酸化ストレスや抗原レセプターの関与で誘導される細胞内のシグナル伝達において決定的な役割を果たしています。また、SYKは乳癌の有効な腫瘍抑制物質として作用すると考えられており、原発性乳癌ではSYKタンパク質の欠如が予後不良と相関しています。SYKが欠損した細胞では運動性の増大がみられますが、これを野生型SYKに置き換えることで正常な状態に回復しています。
Physical form
50 mM Tris-HCl溶液(pH 7.5、150 mM NaCl、0.25mM DTT、0.1 mM EGTA、0.1 mM EDTA、0.1 mM PMSF、25%グリセロール含有)。
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Tomoko Takano et al.
Antioxidants & redox signaling, 4(3), 533-541 (2002-09-07)
Oxidative stress induces the activation of multiple signaling pathways related to various cellular responses. In B cells, Syk has a crucial role in intracellular signal transduction induced by oxidative stress as well as antigen receptor engagement. Treatment of B cells
Christopher S Navara
Current pharmaceutical design, 10(15), 1739-1744 (2004-06-08)
The spleen tyrosine kinase Syk is an enigmatic protein tyrosine kinase functional in a number of diverse cellular processes. It is best known as a non receptor protein tyrosine kinase involved in signal transduction in cells of hematopoietic origin and
Yu Yu et al.
Oncogene, 37(28), 3778-3789 (2018-04-13)
Cell motility and invasiveness are prerequisites for dissemination, and largely account for cancer mortality. We have identified an actionable kinase, spleen tyrosine kinase (SYK), which is keenly tightly associated with tumor progression in ovarian cancer. Here, we report that active
Yu Yu et al.
EBioMedicine, 47, 184-194 (2019-09-08)
Spleen tyrosine kinase (SYK) is frequently upregulated in recurrent ovarian carcinomas, for which effective therapy is urgently needed. SYK phosphorylates several substrates, but their translational implications remain unclear. Here, we show that SYK interacts with EGFR and ERBB2, and directly
関連コンテンツ
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