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Merck

SAB4200678

Anti-Collagen Type I antibody, Mouse monoclonal

clone COL-1, purified from hybridoma cell culture

別名:

Monoclonal Anti-Collagen Type I antibody produced in mouse, OI4, alpha 1, alpha 2, collagen, type I

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この商品について

NACRES:
NA.41
UNSPSC Code:
51111800
Clone:
COL-1, monoclonal
Species reactivity:
pig, rat, human, deer, bovine
Application:
DB, ELISA, IHC
Citations:
20

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biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

COL-1, monoclonal

form

buffered aqueous solution

species reactivity

pig, rat, human, deer, bovine

concentration

~1 mg/mL

technique(s)

ELISA: suitable, dot blot: suitable, immunoblotting: 1-2 μg/mL using recombinant human collagen, expressed in Nicotiana tabacum, immunohistochemistry: 3.5-7 μg/mL using frozen sections of human tonsil, human tongue or pig tongue

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

300

Gene Information

human ... COL1A1(1277)

General description

Collagen type Iα1 (COL1A1) is encoded by the gene that is located on human chromosome 17q21.33. It is the most abundant extracellular matrix (ECM) protein in humans. Type 1 collagen is the major structural protein of bone, tendon, skin and cornea. The encoded protein is a heterotrimer consisting of two α1-chains and one α2-chain.
Collagens are present in the extracellular matrix and contains a chains which can differ in length.

Immunogen

bovine skin collagen type I

Application

Monoclonal Anti-Collagen Type I antibody produced in mouse has been used in immunohistochemical analysis and in vitro invasion assays.

Biochem/physiol Actions

Collagen, type I (COL1A1) is an important component of the connective tissue matrix. It plays an important role in the growth and maintenance of organ and tissue integrity. This protein also participates in the process of tissue repair. COL1A1 is implicated in fibrosis.
Collagens are involved in structural roles. Additionally, they associate with various receptors and control cell proliferation, migration as well as differentiation.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

SAB4200678-VAR: + SAB4200678-100UL: + SAB4200678-BULK:

jan

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試験成績書（COA）

Lot/Batch Number
0000453499
0000453499
0000378307
0000363197
0000363196

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文書ライブラリにアクセスする

María Antonia Martínez-Pascual et al.
International journal of molecular sciences, 25(14) (2024-07-27)
Androgenic alopecia (AGA) is the most common type of alopecia and its treatments involve drugs that have various adverse effects and are not completely effective. Radiofrequency-based therapies (RF) are an alternative for AGA treatment. Although there is increasing clinical evidence
Paeoniflorin prevents postoperative peritoneal adhesion formation in an experimental rat model.
Gao Q, et al.
Oncotarget, 8(55), 93899-93899 (2017)
Overexpression of CXCR4 promotes invasion and migration of non?small cell lung cancer via EGFR and MMP?9.
Zuo J, et al.
Oncology Letters, 14(6), 7513-7521 (2017)
Helical mutations in type I collagen that affect the processing of the amino-propeptide result in an Osteogenesis Imperfecta/Ehlers-Danlos Syndrome overlap syndrome.
Malfait F, et al.
Orphanet Journal of Rare Diseases, 8(1), 78-78 (2013)
Experimental murine myopia induces collagen type Iα1 (COL1A1) DNA methylation and altered COL1A1 messenger RNA expression in sclera.
Zhou X, et al.
Molecular Vision, 18, 1312-1312 (2012)
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関連コンテンツ

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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