コンテンツへスキップ
Merck

SAB4200721

Anti-GABA antibody, Mouse monoclonal

clone GB-69, purified from hybridoma cell culture

別名:

Mouse Anti-Gamma-aminobutyric acid

ログインで組織・契約価格をご覧ください。

サイズを選択してください

この商品について

NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
GB-69, monoclonal
Species reactivity:
rat, monkey, frog, mouse, human, gerbil
Application:
DB, ELISA, IF, IHC
Citations:
4

主要文書

すべての文書を表示
テクニカルサービス
お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。
お手伝いします
テクニカルサービス
お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。
お手伝いします

biological source

mouse

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

GB-69, monoclonal

form

buffered aqueous solution

species reactivity

rat, monkey, frog, mouse, human, gerbil

concentration

~1.0 mg/mL

technique(s)

ELISA: suitable, dot blot: suitable, immunofluorescence: 5-10 μg/mL using human pancreatic tumor AsPC1 cell line, immunohistochemistry: 1-2.5 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human brain and/or cerebellum sections

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... GABRA1(2554)
mouse ... Gabra1(14394)
rat ... Gabra1(29705)
rhesus monkey ... Gabra1(574302)

General description

Anti-GABA antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the GB-69 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified GABA conjugated to BSA. γ-Aminobutyric acid (GABA) is present in the central nervous system (CNS) of vertebrates. GABA is formed following enzymatic decarboxylation of L-glutamic acid by glutamic acid decarboxylase (GAD).

Immunogen

purified GABA conjugated to BSA

Application

Anti-GABA antibody, Mouse monoclonal has been used in:
  • immunofluorescence
  • immunohistochemistry
  • enzyme linked immunosorbent assay (ELISA)
  • dot-blot

Biochem/physiol Actions

γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter. GABA mediates fast synaptic inhibition in the mature nervous system and plays multiple key roles as sensory circuits undergo functional development. GABA promotes proliferation of immune cells, embryonic stem cells and cortical progenitor cells. In addition, it is involved in protein synthesis and metabolism and plays a major role in the regulation of muscle tone, blood pressure, heart rate and respiration.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

適切な製品が見つかりませんか。  

製品選択ツール.をお試しください

保管分類

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

SAB4200721-VAR: + SAB4200721-BULK: + SAB4200721-100UL:

jan

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number
0000444884
0000444884
0000395427
0000395427
0000342526

適切なバージョンが見つかりませんか。

特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

COAを検索

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Distribution of glycine immunoreactivity in the brain of the Siberian sturgeon (Acipenser baeri): Comparison with gamma-aminobutyric acid
Adrio F, et al.
The Journal of Comparative Neurology, 519(6), 1115-1142 (2011)
GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium
Ring H, et al.
PLoS ONE, 7(5), e36874-e36874 (2012)
Kunihiko Obata
Proceedings of the Japan Academy. Series B, Physical and biological sciences, 89(4), 139-156 (2013-04-12)
Signal transmission through synapses connecting two neurons is mediated by release of neurotransmitter from the presynaptic axon terminals and activation of its receptor at the postsynaptic neurons. γ-Aminobutyric acid (GABA), non-protein amino acid formed by decarboxylation of glutamic acid, is
Wei Fan et al.
eLife, 10 (2021-05-28)
Sphingolipids are important structural components of cell membranes and prominent signaling molecules controlling cell growth, differentiation, and apoptosis. Sphingolipids are particularly abundant in the brain, and defects in sphingolipid degradation are associated with several human neurodegenerative diseases. However, molecular mechanisms

関連コンテンツ

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

製品に関するお問い合わせはこちら（テクニカルサービス）