SAB4500437
Anti-Claudin 7 antibody produced in rabbit
affinity isolated antibody
別名:
CEPTRL2, claudin 7, claudin 9, claudin-1, claudin-7
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この商品について
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 22 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CLDN7(1366)
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General description
Anti-Claudin 7 Antibody detects endogenous levels of total Claudin 7 protein.
Claudin 7 is a tight junction membrane protein that belongs to claudins (cld) family. It is upregulated at high level in the upper gastrointestinal tract and the liver. It is located on human chromosome 17p13.
Immunogen
The antiserum was produced against synthesized peptide derived from human Claudin 7.
Immunogen Range: 162-211
Immunogen Range: 162-211
Biochem/physiol Actions
In HCC827 and NCI-H358 lung cancer cells, suppression of claudin-7 decreases the expression of integrin β1. Claudins are important constituents of tight junctions (TJ) in the upper region of epithelial cells.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
SAB4500437-100UG:
jan
Harold Love et al.
Tissue engineering. Part A, 26(19-20), 1091-1098 (2020-04-22)
Patient-oriented applications of cell culture include cell therapy of organ failure like chronic renal failure. Clinical deployment of a cell-based device for artificial renal replacement requires qualitative and quantitative fidelity of a cultured cell to its in vivo counterpart. Active
A non-tight junction function of claudin-7-Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment
Lu Z, et al.
Molecular Cancer (2015)
The claudins
Lal-Nag M and Morin P J
Genome Biology (2009)
The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities
Heiler S, et al.
Cell communication and signaling : CCS (2015)
Sijo Mathew et al.
Development (Cambridge, England), 144(22), 4148-4158 (2017-10-11)
Kidney collecting system development requires integrin-dependent cell-extracellular matrix interactions. Integrins are heterodimeric transmembrane receptors consisting of α and β subunits; crucial integrins in the kidney collecting system express the β1 subunit. The β1 cytoplasmic tail has two NPxY motifs that
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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