SML0006
CK-666
≥98% (HPLC), powder, Arp2/3 comple inhibitor
別名:
2-フルオロ-N-[2-(2-メチル-1H-インドール-3-イル)エチル]-ベンズアミド, CK 666, CK-0944666
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この商品について
実験式（ヒル表記法）:
C18H17FN2O
CAS番号:
分子量:
296.34
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
製品名
CK-666, ≥98% (HPLC), powder
SMILES string
Cc1[nH]c2ccccc2c1CCNC(=O)c3ccccc3F
InChI
1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
InChI key
UXRKUKRXVWJFER-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥25 mg/mL
storage temp.
2-8°C
Quality Level
関連するカテゴリー
Application
CK-666は、細胞のArp2/3による構造変化を研究するために用いられます。
Biochem/physiol Actions
CK-666はArp2/3複合体と結合して、複合体の不活性状態を安定化させて活性配座への移行を防止します。
CK-666は、アクチン関連タンパク質Arp2/3複合体によって仲介されるアクチン集合体の細胞透過性阻害剤です。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Satoko Sakamoto et al.
PLoS biology, 16(9), e2004874-e2004874 (2018-09-27)
Formin is one of the two major classes of actin binding proteins (ABPs) with nucleation and polymerization activity. However, despite advances in our understanding of its biochemical activity, whether and how formins generate specific architecture of the actin cytoskeleton and
Byron Hetrick et al.
Chemistry & biology, 20(5), 701-712 (2013-04-30)
Actin-related protein 2/3 (Arp2/3) complex is a seven-subunit assembly that nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to Arp2/3 complex and inhibit nucleation, but their modes of action are unknown. Here, we use biochemical and structural
Akriti Prashar et al.
Frontiers in cellular and infection microbiology, 8, 133-133 (2018-05-19)
Legionella pneumophila (Lp) exhibits different morphologies with varying degrees of virulence. Despite their detection in environmental sources of outbreaks and in respiratory tract secretions and lung autopsies from patients, the filamentous morphotype of Lp remains poorly studied. We previously demonstrated
Aaron S Dhanda et al.
mBio, 9(2) (2018-04-11)
Palladin is an important component of motile actin-rich structures and nucleates branched actin filament arrays in vitro Here we examine the role of palladin during Listeria monocytogenes infections in order to tease out novel functions of palladin. We show that
Shao-Chen Sun et al.
PloS one, 6(4), e18392-e18392 (2011-04-16)
Mammalian oocyte meiotic maturation involves oocyte polarization and a unique asymmetric division, but until now, the underlying mechanisms have been poorly understood. Arp2/3 complex has been shown to regulate actin nucleation and is widely involved in a diverse range of
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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