SML0203
iCRT14
≥98% (HPLC), Wnt / β-catenin pathway inhibitor, powder
別名:
5-[[2,5-ジメチル-1-(3-ピリジニル)-1H-ピロール-3-イル]メチレン]-3-フェニル-2,4-チアゾリジンジオン
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この商品について
実験式（ヒル表記法）:
C21H17N3O2S
CAS番号:
分子量:
375.44
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
製品名
iCRT14, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
Cc1cc(\C=C2/SC(=O)N(c3ccccc3)C2=O)c(C)n1-c4cccnc4
InChI
1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
InChI key
NCSHZXNGQYSKLR-UNOMPAQXSA-N
関連するカテゴリー
Application
iCRT14は、Wnt /β-カテニンが仲介する細胞信号伝達の研究に使用することができます。
Biochem/physiol Actions
Wnt/β-カテニンパスウェイインヒビター
iCRT14は β-カテニン感応転写阻害剤のチアゾリジンジオンクラスに属します。iCRT14は Dishevelled蛋白のレベルを低下させ、T-細胞因子（TCF）とDNAとの結合を調整します。 これにより、直腸癌細胞の増殖と腫瘍の成長を一定の割合で減少させることができます。
iCRT14は、Wnt/β-カテニンパスウェイのインヒビターです。カテニン応答性転写(CRT)レポーター遺伝子をはじめ、内在性の遺伝子標的を強力に阻害します。また、iCRT14はβ-カテニンとTCF4の相互作用を用量依存的に破壊し、大腸癌細胞株のG0/G1停止を引き起こすことが報告されています。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Xin Wang et al.
Nature communications, 7, 10633-10633 (2016-02-05)
Cancer stem cells (CSCs) contribute to tumour heterogeneity, therapy resistance and metastasis. However, the regulatory mechanisms of cancer cell stemness remain elusive. Here we identify PCNA-associated factor (PAF) as a key molecule that controls cancer cell stemness. PAF is highly
Caihong Wang et al.
Oncoimmunology, 9(1), 1809947-1809947 (2020-09-18)
In colorectal cancer, Wnt/β-catenin signaling is often aberrantly activated and associated with a T-cell-excluded phenotype which is a major obstacle for many immunotherapies. However, the effects of Wnt/β-catenin inhibition on tumor immunity and immunotherapy remain to be elucidated. In syngeneic
Daiana S Sánchez et al.
Biochemical and biophysical research communications, 512(2), 170-175 (2019-03-19)
This work was aimed to determine the effect of 17β-estradiol (17βE) on cell proliferation in human renal tubular epithelial cells (HRTEC) isolated from kidneys from pediatric subjects, as well as the role of estrogen receptors involved in the 17βE proliferative
Shiori Aono et al.
International journal of molecular sciences, 20(13) (2019-07-11)
Remarkable upregulation of the NRF2 (NFE2L2)-related transcription factor NRF3 (NFE2L3) in several cancer tissues and its correlation with poor prognosis strongly suggest the physiological function of NRF3 in tumors. Indeed, we had recently uncovered the function of NRF3, which promotes
Sohee Jun et al.
Nature communications, 7, 10994-10994 (2016-03-25)
Despite the implication of Wnt signalling in radioresistance, the underlying mechanisms are unknown. Here we find that high Wnt signalling is associated with radioresistance in colorectal cancer (CRC) cells and intestinal stem cells (ISCs). We find that LIG4, a DNA
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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