SRP3044
Flt-3/リガンド ヒト
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
別名:
Fms-関連チロシンキナーゼ3 リガンド
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この商品について
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
≥98% (HPLC)
≥98% (SDS-PAGE)
≥98% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
17.6 kDa
製品名
Flt-3/リガンド ヒト, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
biological source
human
recombinant
expressed in E. coli
assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
potency
≤10 ng/mL ED50 ((OCI-AML5 cell proliferation))
mol wt
17.6 kDa
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
white to off-white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... FLT3LG(2323)
関連するカテゴリー
Preparation Note
バイアルは、開封前に遠心してください。水で0.1～1.0 mg/mLに復元してください。ボルテックスは使用しないでください。水溶液は2～8°Cで最長1週間保存できます。長期保存には、担体タンパク質(5%トレハロースなど)含有バッファーでさらに希釈し、1回の使用量ずつに分注して-20～-80°Cで保存することを推奨します。
Biochem/physiol Actions
FLT3LG (Fms-related tyrosine kinase 3 ligand) is a hematopoietic growth factor. It plays a significant role in the development of myeloid and plasmacytoid dendritic cells. It is also involved in the expansion of Treg (T regulatory) cells, thereby offering treatment for autoimmune disorders and transplantation processes. FLT3LG is associated with autoimmune arthritis, for instance rheumatoid arthritis and primary Sjogren′s syndrome. FLT3LG along with FLT3 is involved in the proliferation of primary AML (acute myeloid leukemia) blasts and autocrine signaling in AML.
General description
FLT3LG (Fms-related tyrosine kinase 3 ligand) is a transmembrane glycoprotein and a ligand for FLT3 receptor. It is widely expressed in human tissues. The protein exists in membrane bound as well as secreted forms. Binding of FLT3LG to FLT3 results in receptor dimerization, activation of the tyrosine kinase domain, autophosphorylation and thereby activation of the receptor. Recombinant human Flt3-Ligand is a soluble 17.6kDa protein consisting of 155 amino acid residues.
Other Notes
MTQDCSFQHS PISSDFAVKI RELSDYLLQD YPVTVASNLQ DEELCGGLWR LVLAQRWMER LKTVAGSKMQ GLLERVNTEI HFVTKCAFQP PPSCLRFVQT NISRLLQETS EQLVALKPWI TRQNFSRCLE LQCQPDSSTL PPPWSPRPLE ATAPT
Physical form
Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 50 mM NaCl, pH 7.5
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
SRP3044-10UG:
jan
Serum concentrations of Flt-3 ligand in rheumatic diseases.
Nakamura K, et al.
Bioscience Trends, 9, 342-342 (2015)
Further activation of FLT3 mutants by FLT3 ligand.
Zheng R, et al.
Oncogene, 30, 4004-4004 (2011)
FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis in rheumatoid arthritis.
Ramos MI, et al.
Arthritis Research & Therapy, 15, R209-R209 (2013)
Flt3 ligand expands CD4+ FoxP3+ regulatory T cells in human subjects.
Klein O, et al.
European Journal of Immunology, 43, 533-533 (2013)
K Mackarehtschian et al.
Immunity, 3(1), 147-161 (1995-07-01)
The flk2 receptor tyrosine kinase has been implicated in hematopoietic development. Mice deficient in flk2 were generated. Mutants developed into healthy adults with normal mature hematopoietic populations. However, they possessed specific deficiencies in primitive B lymphoid progenitors. Bone marrow transplantation
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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