SRP3084
IL-1RA ヒト
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
別名:
ICIL-1RA, IL-1RN, IRAP
ログインで組織・契約価格をご覧ください。
サイズを選択してください
この商品について
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
≥98% (HPLC)
≥98% (SDS-PAGE)
≥98% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
17.2 kDa
製品名
IL-1RA ヒト, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
biological source
human
recombinant
expressed in E. coli
assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
potency
20-40 ng/mL
mol wt
17.2 kDa
packaging
pkg of 100 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
white to off-white
suitability
suitable for molecular biology
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL1R1(3554)
Physical form
凍結乾燥品(5mM Tris、pH 8.0、25 mM NaCl)
Preparation Note
バイアルは、開封前に遠心してください。水で濃度0.1～1.0mg/mLに復元してください。ボルテックスは行なわないでください。水溶液は2～8°Cで最長1週間保存できます。長期保存には、担体タンパク質(0.1% BSAなど)含有バッファーでさらに希釈し、1回の使用量ずつに分注して-20～-80°Cで保存することを推奨します。
Application
IL-1Ra human has been used as an IL1 antagonist to block the signaling from the IL1 receptor and verify that IL1 signaling is responsible for invasiveness in CD133-expressing cells. It has also been used as a control in sandwich enzyme-linked immunosorbent assay (ELISA) to measure protein levels.
Biochem/physiol Actions
Interleukin-1 receptor antagonist (IL-1RA) inhibits the activity of IL-1α (interleukin 1 α) and IL-1β (interleukin 1 β) by competitively blocking binding to their type I and type II receptors. Therapeutically, IL-1RA may help in the treatment of sepsis, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Low production of IL-1RA is observed in HIV-1 (human immunodeficiency virus 1)-infected dendritic cells.
The interleukin-1 receptor antagonist (IL-1Ra) functions as a specific and selective competitive inhibitor of IL-1R1, binding to the receptor with high affinity.
General description
Research Area: IMMUNO AND CKS
The interleukin-1 receptor antagonist (IL-1Ra) is part of the IL-1 family and binds to IL-1 receptors without triggering any intracellular response. IL-1Ra, produced by hepatic cells, exhibits characteristics of an acute phase protein. Endogenous IL-1Ra is generated in various experimental animal models of disease, as well as in human autoimmune and chronic inflammatory conditions.
The interleukin-1 receptor antagonist (IL-1Ra) is part of the IL-1 family and binds to IL-1 receptors without triggering any intracellular response. IL-1Ra, produced by hepatic cells, exhibits characteristics of an acute phase protein. Endogenous IL-1Ra is generated in various experimental animal models of disease, as well as in human autoimmune and chronic inflammatory conditions.
The gene IL-1RA (interleukin-1 receptor antagonist) is mapped to human chromosome 2q. It belongs to the IL-1 (interleukin 1) family of proteins. The encoded protein has a TIR (Toll/IL-1 receptor) domain. IL-1RA is produced by corneal epithelial cells, monocytes, neutrophils, macrophages and fibroblasts. It is a naturally occurring inflammatory inhibitor protein. Recombinant human IL-1RA is a 17.2kDa protein consisting of 153 amino acid residues.
Other Notes
MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
SRP3084-100UG:
jan
Interleukin-1 beta, interleukin-1 receptor antagonist and interleukin-6 plasma levels and cytokine gene polymorphisms in chronic lymphocytic leukemia: correlation with prognostic parameters.
Hulkkonen J
Haematologica, 85, 600-606 (2000)
Colonic explant production of IL-1and its receptor antagonist is imbalanced in inflammatory bowel disease (IBD).
Dionne S
Clinical and Experimental Immunology, 112, 435-442 (1998)
Recombinant interleukin-1 receptor antagonist (IL-1ra): effective therapy against gram-negative sepsis in rats.
Alexander HR
Surgery, 112, 188-193 (1992)
Interleukin-1 receptor antagonist: role in biology.
Arend WP
Annual Review of Immunology, 16, 27-55 (1998)
IL-1B and IL-1Ra gene polymorphisms and disease severity in rheumatoid arthritis: interaction with their plasma levels.
Buchs N
Genes and Immunity, 2, 222-228 (2001)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）