T1408
ホロトランスフェリン ウシ
別名:
シデロフィリン, シデロフィリン, 鉄飽和
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この商品について
Form:
powder
Assay:
97-100% (agarose gel electrophoresis)
Biological source:
bovine
biological source
bovine
assay
97-100% (agarose gel electrophoresis)
form
powder
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
2-8°C
Quality Level
Gene Information
bovine ... TF(280705)
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Biochem/physiol Actions
Studies show that treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.
Holo-Transferrin (holo-Tf) or the iron bound transferrin functions as an iron sequester and is crucial for defense against microbial infections. Transferrin is used as a model system for understanding the kinetics and dynamics of protein structure based interactions. It is a potential candidate for delivery studies for its ability to cross the blood-brain barrier. The interaction of holo-Tf with thrombin is implicated in the pathogenesis of intracerebral hemorrhage. Polymorphisms in the bovine transferrin gene has led to the generation of 10 variant transferrin protein.
General description
Holo-Transferrin is an iron transporting glycoprotein and belongs to metalloprotein class. The gene encoding transferrin is mapped to bovine chromosome 1.
Analysis Note
アガロ-スゲル電気泳動によって純度測定。
Application
Holo-Transferrin bovine has been used:
- as a RPMI-1640 medium supplement for culturing cancer cell lines
- as a component of visceral fat differentiation medium for the pre-adipocytes primary cell culture
- to test the influence of iron-saturation complex on the growth of Malassezia pachydermatis
- as a standard for strong anion exchange (SAX) reactor measurements
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
T1408-500MG: + T1408-50MG: + T1408-1G: + T1408-VAR: + T1408-BULK: + T1408-100MG:
jan
Holo-transferrin and thrombin can interact to cause brain damage
Nakamura T, et al.
Stroke, 36(2), 348-352 (2005)
Transferrin as a model system for method development to study structure, dynamics and interactions of metalloproteins using mass spectrometry
Kaltashov IA, et al.
Biochim. Biophys. Acta Gen. Subj., 1820(3), 417-426 (2012)
Jillian R Gunther et al.
ACS chemical biology, 4(6), 435-440 (2009-05-16)
Compounds that directly disrupt the androgen receptor/steroid receptor coactivator interaction could function as novel inhibitors of androgen signaling that would remain effective in the treatment of prostate cancer that is resistant to conventional endocrine therapies. A structure-based peptidomimetic approach was
A single nucleotide polymorphism in the coding region of bovine transferrin is associated with milk fat yield
Sanz A, et al.
Genetics and molecular research : GMR, 9(2), 843-848 (2010)
Metabolic restriction of cancer cells in vitro causes karyotype contraction?an indicator of cancer promotion?
Li Y, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 33(1), 195-205 (2012)
関連コンテンツ
Product Information Sheet
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