T5694
TRAIL ヒト
recombinant, expressed in NSO cells, >97% (SDS-PAGE), lyophilized powder
別名:
Apo2L, Apo2リガンド, TL2, TNF関連アポトーシス誘導性リガンド
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この商品について
Form:
lyophilized powder
Assay:
>97% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in NSO cells
Mol wt:
24 kDa by SDS-PAGE
predicted mol wt ~21 kDa
predicted mol wt ~21 kDa
製品名
TRAIL ヒト, recombinant, expressed in NSO cells, >97% (SDS-PAGE), lyophilized powder
biological source
human
recombinant
expressed in NSO cells
description
N-terminal 6X histidine-tagged extracellular domain
assay
>97% (SDS-PAGE)
form
lyophilized powder
mol wt
24 kDa by SDS-PAGE
predicted mol wt ~21 kDa
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... TNFSF10(8743)
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Analysis Note
アクチノマイシンD存在下で、マウスL-929細胞での細胞毒性を誘導します。
Biochem/physiol Actions
TNFス-パ-ファミリ-の膜貫通タンパク質 II 型です。アポト-シスを誘導性デスレセプタ-のDR4, DR5、デコイレセプタ-のDcR1, DcR2、オステオプロテゲリンに対するリガンドです。FASリガンドとのアミノ酸配列の一致率は約28%です。ヒトTRAILとマウスTRAILとの配列の一致率は約65%です。
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. It is present in both soluble as well as membrane-bound form and can induce rapid apoptosis of various transformed cell lines but not the normal cells. Additionally, the product can also induces apoptotic cell death in TRAIL-sensitive U343MGcells.
Physical form
結乾燥品 (PBS, 0.5mg BSA含有, 0.2μmフィルタ-濾過)
Application
TRAIL human was used to induce cytotoxicity in A549, a human lung carcinoma cell line.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
T5694-10UG-PW: + T5694-10UG: + T5694-BULK: + T5694-VAR:
jan
J Sträter et al.
Annals of the New York Academy of Sciences, 915, 162-170 (2001-02-24)
The tumor necrosis factor receptor (TNFR) family is a still-growing group of homologous transmembrane proteins, some of which bear an intracellular "death domain" and are able to directly mediate apoptosis. Apoptosis is induced upon trimerization of the receptors by their
Bich Hang Do et al.
Journal of microbiology and biotechnology, 27(12), 2156-2164 (2017-10-17)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered as an antitumor agent owing to its ability to induce apoptosis of cancer cells without imparting toxicity toward most normal cells. TRAIL is produced in poor yield because of its insoluble expression
X D Zhang et al.
FEBS letters, 482(3), 193-199 (2000-10-12)
Resistance of normal cells to tumour necrosis factor related apoptosis inducing ligand (TRAIL) induced apoptosis is believed to be mediated by expression of two decoy receptors. Here we show that the expression and localisation of TRAIL receptors (TRAIL-Rs) vary between
W S Simonet et al.
Cell, 89(2), 309-319 (1997-04-18)
A novel secreted glycoprotein that regulates bone resorption has been identified. The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily. In vivo, hepatic expression of OPG in transgenic mice results in a profound yet nonlethal
Matthew J Coussens et al.
Journal of visualized experiments : JoVE, (58)(58), doi:10-doi:10 (2012-01-05)
RNA interference (RNAi) is an intrinsic cellular mechanism for the regulation of gene expression. Harnessing the innate power of this system enables us to knockdown gene expression levels in loss of gene function studies. There are two main methods for
関連コンテンツ
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