T9701
TRAIL ヒト
recombinant, expressed in E. coli, ≥98% (SDS-PAGE and HPLC), lyophilized powder
別名:
Apo2L, Apo2リガンド, TL2, TNF関連アポトーシス誘導性リガンド
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この商品について
Form:
lyophilized powder
Assay:
≥98% (SDS-PAGE and HPLC)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
19.6 kDa, predicted mol wt ~21 kDa
biological source
human
recombinant
expressed in E. coli
description
extracellular domain
assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
mol wt
19.6 kDa, predicted mol wt ~21 kDa
technique(s)
immunofluorescence: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... TNFSF10(8743)
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Biochem/physiol Actions
TNFス-パ-ファミリ-の膜貫通タンパク質 II 型です。アポト-シスを誘導性デスレセプタ-のDR4, DR5、デコイレセプタ-のDcR1, DcR2、オステオプロテゲリンに対するリガンドです。FASリガンドとのアミノ酸配列の一致率は約28%です。ヒトTRAILとマウスTRAILとの配列の一致率は約65%です。
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. The product present in both soluble as well as membrane-bound form, can induce rapid apoptosis of various transformed cell lines but not the normal cells. Additionally, the product can also induce apoptotic cell death in TRAIL-sensitive U343MG cells.
TRAIL is a cytokine with anti-inflammatory, and antitumor activity. It is expressed in various cells including immune cells, vascular cells and adipocytes. TRAIL is associated with vascular endothelial cell protection.
Physical form
凍結乾燥品(PBS溶液)
Analysis Note
The biological activity is determined by its ability to induce apoptotic cell death in TRAIL-sensitive LN-18 cells.
Application
Human TRAIL can be used as a selection agent for treating human cells for phenotypic enrichments. The product can also be used in chemical transfection for identifying Small RNA Modulators of TRAIL-Induced Apoptosis Pathway by utilizing libraries of synthetic small interfering RNA (siRNA) and microRNAs (miRNA).
TRAIL human has been used in immunofluorescence analyses, to study the delocalization of melanoma antigen-D2 in the nucleoplasm after a cellular stress.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
T9701-10UG: + T9701-BULK: + T9701-20UG: + T9701-20UG-PW: + T9701-VAR:
jan
Synergistic effect of TRAIL and irradiation in elimination of glioblastoma stem-like cells
Liu J, et al.
Clinical and Experimental Medicine, 1-13 (2018)
Fatih Birtekocak et al.
Iranian journal of pharmaceutical research : IJPR, 20(2), 45-56 (2021-09-28)
Colon cancer is one of the most prominent causes of cancer-related morbidity and mortality and curable if detected in the early stages. TNF-related apoptosis-inducing ligand (TRAIL) is a therapeutic protein and has a potential anti-cancer activity that is widely used
Lower maternal serum tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) levels in early preeclampsia. A retrospective study
Morano D, et al.
Pregnancy hypertension, 12, 1-5 (2018)
Dmitriy Ovcharenko et al.
Cancer research, 67(22), 10782-10788 (2007-11-17)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to death receptors 4/5 and selectively induces caspase-dependent apoptosis. The RNA interference screening approach has led to the discovery and characterization of several TRAIL pathway components in human cells. Here, libraries of synthetic
Jan E Carette et al.
Nature biotechnology, 29(6), 542-546 (2011-05-31)
Insertional mutagenesis in a haploid background can disrupt gene function. We extend our earlier work by using a retroviral gene-trap vector to generate insertions in >98% of the genes expressed in a human cancer cell line that is haploid for
関連コンテンツ
Instructions
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