V9134
モノクローナル抗血管内皮増殖因子受容体-2抗体 マウス宿主抗体
clone KDR-1, ascites fluid
別名:
抗KDR抗体, 抗VEGF R-2抗体
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この商品について
Conjugate:
unconjugated
Clone:
KDR-1, monoclonal
Application:
immunohistochemistry (frozen sections)
indirect ELISA
indirect ELISA
Species reactivity:
human
Citations:
25
Technique(s):
immunohistochemistry (frozen sections): 1:800 using human placenta
indirect ELISA: suitable
indirect ELISA: suitable
Uniprot accession no.:
製品名
モノクローナル抗血管内皮増殖因子受容体-2抗体 マウス宿主抗体, clone KDR-1, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
KDR-1, monoclonal
contains
15 mM sodium azide
species reactivity
human
technique(s)
immunohistochemistry (frozen sections): 1:800 using human placenta
indirect ELISA: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KDR(3791)
関連するカテゴリー
General description
VEGFレセプタ-2(KDR)と特異的に結合します。VEGFレセプタ-1(Flt1受容体)、VEGFレセプタ-3(sFlt4)、PDGF-Rβは認識しません。
Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 (mouse IgG1 isotype) is derived from the KDR-1 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Vascular endothelial growth factor (VEGF), is a homodimeric heparin-binding glycoprotein. It is a member of a family of endothelial cell mitogenic and angiogenic factors. The VEGFR2 gene has been mapped to human chromosome 4q11-q12, which is the same locus for PDGF receptor and c-kit.
Immunogen
VEGFR-2(KDR)の組み換えヒト細胞外ドメインです。
Application
Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse has been used in:
- immunohistochemistry
- histology
- immunostaining
- enzyme linked immunosorbent assay (ELISA)
Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse was used for FACS analysis of HUVECs.
Biochem/physiol Actions
Vascular endothelial growth factor (VEGF) specifically stimulates the proliferation of endothelial cells isolated from both small and large vessels. These include endothelial cells from adrenal cortex, cerebral cortex, fetal and adult aorta and human umbilical vein.
Vascular endothelial growth factors receptors (VEGF Rs) are receptor tyrosine kinases that bind to VEGF. VEGF plays an important role in embryonic vasculogenesis, angiogenesis and homeostasis. The binding of VEGF to VEGF R2 results in activation of MAPK, PI3K, PKC, FAK and Src kinase pathways. The biological roles of VEGF R2 include in epithelial cell growth, proliferation, survival, migration, vascular permeability and angiogenesis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
V9134-VAR: + V9134-.2ML: + V9134-BULK:
jan
Markus Meissner et al.
Circulation research, 94(3), 324-332 (2003-12-20)
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors, originally implicated in the regulation of lipid and glucose homeostasis. In addition, natural and synthetic PPAR activators may control inflammatory processes by inhibition of distinct proinflammatory genes. As signaling via the vascular
Chie-Pein Chen et al.
Stem cells (Dayton, Ohio), 26(2), 550-561 (2007-11-03)
Maternal cells can become engrafted in various fetal organs during pregnancy. The nature of the cells and the mechanisms of maternofetal cell trafficking are not clear. We demonstrate that human lineage-negative, CD34-negative (Lin(-)CD34(-)) multipotent mesenchymal stromal cells express alpha(2), alpha(4)
Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors
Masood R, et al.
Blood, 98(6), 1904-1913 (2001)
Axitinib affects cell viability and migration of a primary foetal lung adenocarcinoma culture
Menna C, et al.
Cancer Investigation, 32(1), 13-21 (2014)
Impact of VEGF, VEGFR, PDGFR, HIF and ERCC1 gene polymorphisms on thymic malignancies outcome after thymectomy
Berardi R, et al.
Testing, 6(22), 19305-19305 (2015)
関連コンテンツ
Instructions
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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