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Merck

PHR1017

Phenylephrine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

동의어(들):

(R)-(−)-Phenylephrine hydrochloride, PHE, (R)-(−)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride, (R)-(−)-3-Hydroxy-α-(methylaminomethyl)benzyl alcohol hydrochloride

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
HOC6H4CH(CH2NHCH3)OH·HCl
CAS 번호:
61-76-7
Molecular Weight:
203.67
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823048
EC Number:
200-517-3
Beilstein/REAXYS Number:
4158948
MDL number:
MFCD00012605

주요 문서

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InChI key

OCYSGIYOVXAGKQ-FVGYRXGTSA-N

InChI

1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1

SMILES string

OC1=CC([C@H](CNC)O)=CC=C1.Cl

grade

certified reference material, pharmaceutical secondary standard

agency

USP 1533002, traceable to Ph. Eur. P1250000

API family

phenylephrine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

143-145 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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관련 카테고리

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Phenylephrine Hydrochloride is classified under the category of sympathomimetic drugs. It is generally utilized as a nasal decongestant.

Application

Phenylephrine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and spectrophotometry techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7786 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H317

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1B

저장 등급

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Simultaneous high performance liquid chromatographic and derivative ratio spectra spectrophotometry determination of chlorpheniramine maleate and phenylephrine hydrochloride
Erk N and Kartal M
Il Farmaco (Societa Chimica Italiana : 1989), 53(8-9), 617-622 (1998)
Degradation of phenylephrine hydrochloride in tablet formulations containing aspirin
Troup AE and Mitchner H
Journal of Pharmaceutical Sciences, 53(4), 375-379 (1964)
Determination of phenylephrine hydrochloride and chlorpheniramine maleate in binary mixture using chemometric-assisted spectrophotometric and high-performance liquid chromatographic-UV methods
Al-Shaalan NH
Journal of Saudi Chemical Society, 14(1), 15-21 (2010)
Development and validation of a novel RP-HPLC method for simultaneous determination of paracetamol, phenylephrine hydrochloride, caffeine, cetirizine and nimesulide in tablet formulation.
Dewani AP, et al.
Arabian Journal of Chemistry, 8(4), 591-598 (2015)
Dale A Currigan et al.
Anesthesiology, 121(5), 930-936 (2014-09-10)
Vasopressor drugs, commonly used to treat systemic hypotension and maintain organ perfusion, may also induce regional vasoconstriction in specialized vascular beds such as the lung. An increase in pulmonary vascular tone may adversely affect patients with pulmonary hypertension or right
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