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Merck

1225703

USP

Doxorubicin hydrochloride

United States Pharmacopeia (USP) Reference Standard

동의어(들):

Adriamycin hydrochloride, DOX, Hydroxydaunorubicin hydrochloride

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C27H29NO11 · HCl
CAS 번호:
25316-40-9
Molecular Weight:
579.98
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329749677
MDL number:
MFCD00077757
Beilstein/REAXYS Number:
4229251

주요 문서

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SMILES string

Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

InChI key

MWWSFMDVAYGXBV-RUELKSSGSA-N

InChI

1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

grade

pharmaceutical primary standard

API family

doxorubicin

manufacturer/tradename

USP

mp

216 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

Gene Information

human ... TOP2A(7153)

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관련 카테고리

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Doxorubicin hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Doxorubicin Hydrochloride Injection
  • Doxorubicin Hydrochloride for Injection
  • Epirubicin Hydrochloride
  • Epirubicin Hydrochloride Injection

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Doxorubicin Hydrochloride Injection
United States Pharmacopeia, 42(4), 1514-1514 (2022)
Doxorubicin Hydrochloride for Injection
United States Pharmacopeia, 40(4), 1516-1516 (2022)
Doxorubicin Hydrochloride
United States Pharmacopeia, 40(3), 1512-1512 (2020)
C Main et al.
Health technology assessment (Winchester, England), 10(9), 1-132 (2006-03-21)
To examine the clinical effectiveness and cost-effectiveness of intravenous formulations of topotecan monotherapy, pegylated liposomal doxorubicin hydorocholoride (PLDH) monotherapy and paclitaxel used alone or in combination with a platinum-based compound for the second-line or subsequent treatment of advanced ovarian cancer.
Xin Ma et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(17), 6389-6394 (2014-04-16)
A critical challenge for chemotherapy is the development of chemoresistance in breast cancer. However, the underlying mechanisms and validated predictors remain unclear. Extracellular vesicles (EVs) have gained attention as potential means for cancer cells to share intracellular contents. In adriamycin-resistant
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