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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
(CH3CH2CH2)2CHCO2H
CAS 번호:
Molecular Weight:
144.21
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
202-777-3
MDL number:
제품 이름
Valproic acid, United States Pharmacopeia (USP) Reference Standard
InChI
1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
InChI key
NIJJYAXOARWZEE-UHFFFAOYSA-N
SMILES string
CCCC(C(O)=O)CCC
grade
pharmaceutical primary standard
API family
valproic acid
manufacturer/tradename
USP
refractive index
n20/D 1.425 (lit.)
bp
220 °C (lit.)
density
0.9 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
Gene Information
human ... ALDH5A1(7915)
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Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application
Valproic acid USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Divalproex Sodium
- Divalproex Sodium Delayed-Release Capsules
- Divalproex Sodium Delayed-Release Tablets
- Divalproex Sodium Extended-Release Tablets
- Valproate Sodium Injection
- Valproic Acid
- Valproic Acid Capsules
Biochem/physiol Actions
Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
flash_point_f
231.8 °F - closed cup
flash_point_c
111 °C - closed cup
Taylor Chomiak et al.
Neurotoxicology and teratology, 36, 57-66 (2012-09-13)
Autism spectrum disorder (ASD) is a behaviourally defined brain disorder affecting approximately 1 in 88 children. Many pathological studies have shown that ASD is frequently associated with grey and white matter changes that can be described by their deviations from
Yu-Fan Chuang et al.
Biochemical pharmacology, 88(3), 372-383 (2014-02-21)
Inflammation and vascular perturbations are increasingly implicated in the pathogenesis of neurodegenerative diseases. Prevailing evidence suggests that valproic acid (VPA), an antiepileptic and mood stabilizer, exhibits not only neuro-protective effects, but also anti-inflammatory effects in neurodegenerative diseases. However, the underlying
Alexa P Vitins et al.
Archives of toxicology, 88(8), 1573-1588 (2014-02-19)
Liver injury is the leading cause of drug-induced toxicity. For the evaluation of a chemical compound to induce toxicity, in this case steatosis or fatty liver, it is imperative to identify markers reflective of mechanisms and processes induced upon exposure
Chi-Tso Chiu et al.
Pharmacological reviews, 65(1), 105-142 (2013-01-10)
The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar disorder (BD), a severe mental illness arising from complex interactions between genes and environment that drive deficits in cellular plasticity and resiliency. The therapeutic potential of
Florence I Roullet et al.
Neurotoxicology and teratology, 36, 47-56 (2013-02-12)
Valproic acid (VPA) is both an anti-convulsant and a mood stabilizer. Clinical studies over the past 40 years have shown that exposure to VPA in utero is associated with birth defects, cognitive deficits, and increased risk of autism. Two recent
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