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Merck

09-217

Anti-Raptor Antibody

Upstate®, from rabbit

Sinónimos:

p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats, regulatory associated protein of mTOR

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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunoprecipitation (IP)
western blot
Species reactivity:
human
Citations:
43
Technique(s):
immunoprecipitation (IP): suitable
western blot: suitable
Uniprot accession no.:
Q8N122

Documentos clave

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Nombre del producto

Anti-Raptor Antibody, Upstate®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_020761.2

UniProt accession no.

Q8N122

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... RPTOR(57521)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

150 kDa

Immunogen

KLH conjugated peptide encompassing the N-terminal region of human Raptor.

Analysis Note

Routinely evaluated by immunoblot.

Application

Detect Raptor using this anti-Raptor Antibody validated for use in IP & WB.
Research Category
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling

Biochem/physiol Actions

Other species have not been tested.

Physical form

Affinity purified rabbit polyclonal IgG in 0.02M PBS, 0.25M sodium chloride containing 0.1% sodium azide and 50% glycerol.
ImmunoAffinity Purified

Preparation Note

2 years at -20°C from date of shipment

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Clase de almacenamiento

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Hiroki Nojima et al.
The Journal of biological chemistry, 278(18), 15461-15464 (2003-02-27)
The mammalian target of rapamycin (mTOR) controls multiple cellular functions in response to amino acids and growth factors, in part by regulating the phosphorylation of p70 S6 kinase (p70S6k) and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1). Raptor (regulatory associated
Dos D Sarbassov et al.
The Journal of biological chemistry, 280(47), 39505-39509 (2005-09-27)
The raptor-mTOR protein complex is a key component of a nutrient-sensitive signaling pathway that regulates cell size by controlling the accumulation of cellular mass. How nutrients regulate signaling through the raptor-mTOR complex is not well known. Here we show that
Identification of the novel interacting partners of the mammalian target of rapamycin complex 1 in human CCRF-CEM and HEK293 cells.
Rahman, H; Qasim, M; Oellerich, M; Asif, AR
International Journal of Molecular Sciences null
Kenta Hara et al.
Cell, 110(2), 177-189 (2002-08-02)
mTOR controls cell growth, in part by regulating p70 S6 kinase alpha (p70alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding protein that also binds 4EBP1 and p70alpha. The binding of raptor
Do-Hyung Kim et al.
Cell, 110(2), 163-175 (2002-08-02)
mTOR/RAFT1/FRAP is the target of the immunosuppressive drug rapamycin and the central component of a nutrient- and hormone-sensitive signaling pathway that regulates cell growth. We report that mTOR forms a stoichiometric complex with raptor, an evolutionarily conserved protein with at
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09-21704053252405389

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