Casein Kinase II Inhibitor III, TBCA

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀ = 110 nM, K_i = 77 nM) with greater selectivity than TBB (Cat. No. 218697 and Cat. No. 218708) and DMAT against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC₅₀ = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.

Cell permeable: yes

Primary Target
CKII

Reversible: yes

Packaged under inert gas

A 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Pagano, M.A., et al. 2006. Chembiochem,8, 129.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Irritant (B)