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400046

Hydroxyurea

Name: Hydroxyurea
Brand: MM

≥98% (HPLC), solid, RNR inhibitor, Calbiochem

Sinónimos:

Hydroxyurea, Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I

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Fórmula empírica (notación de Hill):

CH₄N₂O₂

Número CAS:

127-07-1

Peso molecular:

76.05

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00007943

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze

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Propiedades

Nombre del producto

Hydroxyurea, Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.

Quality Segment

100

description

Merck USA index - 14, 4848

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

water: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

N(O)C(=O)N

InChI

1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)

InChI key

VSNHCAURESNICA-UHFFFAOYSA-N

Descripción

General description

Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.

Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Inhibiting ribonucleotide reductase

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.

Other Notes

Leyden, D., et al. 2000. Anticancer Res.20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

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hcodes

H340,H361

pictograms

GHS08

signalword

Danger

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Muta. 1B - Repr. 2

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c