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Merck

475856

Mdivi-1

≥95% (HPLC), dynamin-related GTPases inhibitor, solid

Sinónimos:

Mitochondrial Division Inhibitor, mdivi-1, Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor, 3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one

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Fórmula empírica (notación de Hill):
C15H10Cl2N2O2S
Número CAS:
338967-87-6
Peso molecular:
353.22
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00974506

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Nombre del producto

Mitochondrial Division Inhibitor, mdivi-1, The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.

SMILES string

Sc1[n]([c](c3c(n1)cccc3)=O)c2c(cc(c(c2)OC)Cl)Cl

InChI

1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)

InChI key

NZJKEVWTYMOYOR-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 10 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Categorías relacionadas

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC50 = 10 and 50 M in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC50<10 M) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release.

Other Notes

Cassidy-Stone A., et al. 2008. Dev. Cell14, 193.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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