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491207

Novobiocin sodium salt

≥90% (HPLC), powder, DNA gyrase inhibitor, Calbiochem®

Sinónimos:

Novobiocin, Sodium Salt

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Fórmula empírica (notación de Hill):
C31H35N2O11 · Na
Número CAS:
1476-53-5
Peso molecular:
634.61
MDL number:
MFCD30207859
UNSPSC Code:
51286504
NACRES:
NA.77
Assay:
≥90% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
OK to freeze, protect from light
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Nombre del producto

Novobiocin, Sodium Salt,

assay

≥90% (HPLC)

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white to yellow

shipped in

ambient

storage temp.

2-8°C

SMILES string

[Na+].N([C-]2C(=O)Oc3c(ccc(c3C)OC4OC(C(C(C4O)OC(=O)N)OC)(C)C)C2=O)C(=O)c1cc(c(cc1)O)CC=C(C)C

InChI

1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1

InChI key

AXOUUAINTJNFRS-UHFFFAOYSA-N

General description

A DNA gyrase inhibitor that can be used for the production of positively supercoiled plasma DNA. Targets the nucleotide-binding site of gyrase B. Exhibits antibacterial properties. Inhibits retrovirus RNA-dependent DNA polymerases. Inhibits LPS-induced production of pro-inflammatory cytokines. Reported to act as a potent inhibitor of ADP ribosylation. Also inhibits protein synthesis and alters the phosphorylation state of several cytosolic proteins.
DNA gyrase inhibitor used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases. Also a potent inhibitor of ADP ribosylation eliminates the wild-type pMG110 plasmid from E. coli.

Biochem/physiol Actions

Cell permeable: no
Primary Target
retrovirus RNA-dependent DNA polymerases
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, refrigerate (4°C). Stock solutions are stable for 3 months at 4°C.

Other Notes

Marcu, M.G., et al. 2000. J. Natl. Cancer Inst.92, 242.
Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp.42, 1911.
Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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pictograms

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GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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