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5.08506

Gabapentin

Name: Gabapentin
Brand: MM

Sinónimos:

Gabapentin, L-type Voltage Gated Ca2+ Channel Blocke, Gabapentin

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Fórmula empírica (notación de Hill):

C₉H₁₇NO₂

Número CAS:

60142-96-3

Peso molecular:

171.24

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00865286

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Propiedades

assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

water: 100 mM

storage temp.

2-8°C

SMILES string

[N+H3]CC1(CCCCC1)CC(=O)[O-]

InChI

1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)

InChI key

UGJMXCAKCUNAIE-UHFFFAOYSA-N

Descripción

General description

A water soluble GABA analog originally developed to treat epilepsy and neuropathic pain but is not believed to act on the same brain receptors. Gabapentin interacts with voltage-gated calcium channels in cortical neurons. It binds to the α2δ subunit (1 and 2) and has been found to reduce calcium currents after chronic but not acute application via an effect on trafficking of voltage-dependent calcium channels in the central nervous system.

Biochem/physiol Actions

Primary Target
α2δ subunit of L-type voltage gated Ca2+ channels

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Eroglu, C. et al. 2009. Cell.139, 380.
Hendrich, J. et al. 2008. Proc. Natl. Acad. Sci. USA105, 3628.
Davies, A. et al. 2007. Trends Pharmacol. Sci.28, 220.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c