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Merck

D0100000

Dapsone

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

4-Aminophenyl sulfone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, Bis(4-aminophenyl) sulfone, DDS, Dapsone

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Fórmula lineal:
(H2NC6H4)2SO2
Número CAS:
80-08-0
Peso molecular:
248.30
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329798581
MDL number:
MFCD00007887
Beilstein/REAXYS Number:
788055

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InChI key

MQJKPEGWNLWLTK-UHFFFAOYSA-N

SMILES string

Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2

InChI

1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2

grade

pharmaceutical primary standard

agency

EP Reference Standard

API family

dapsone

manufacturer/tradename

EDQM

mp

175-177 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dapsone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 1B - STOT RE 2 - STOT SE 2

target_organs

Blood, Blood,spleen,Liver

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Julien Seneschal et al.
Dermatology (Basel, Switzerland), 224(2), 115-119 (2012-04-18)
Dapsone has potent anti-inflammatory effects and remains an effective therapy in a variety of skin disorders: cutaneous vasculitis, neutrophilic dermatoses and blistering disorders. However it may cause a severe idiosyncratic reaction compatible with drug-induced DRESS (drug reaction with eosinophilia and
Dipankar De et al.
Leprosy review, 78(4), 401-404 (2008-03-04)
Dapsone is one of the main constituents of anti-leprosy treatment and has been in use for various dermatological and non-dermatological indications since the 1940s. Dapsone-induced photosensitivity is a rare complication. Only 11 cases seem to have been reported in the
Leon H Kircik
Journal of drugs in dermatology : JDD, 9(6), 667-671 (2010-07-22)
Data continue to establish the role of inflammation, not only in the pathogenesis of acne but also in the development of its most devastating sequelum, scarring. Although topical therapy is preferred by most acne patients and the physicians who treat
Evan W Piette et al.
Dermatologic clinics, 29(4), 561-564 (2011-09-20)
Dapsone is used in the treatment of autoimmune bullous diseases (AIBD), a group of disorders resulting from autoimmunity directed against basement membrane and/or intercellular adhesion molecules on cutaneous and mucosal surfaces. This review summarizes the limited published data evaluating dapsone
Evan W Piette et al.
Immunology and allergy clinics of North America, 32(2), 317-322 (2012-05-09)
Dapsone is used in the treatment of autoimmune bullous diseases (AIBD), a group of disorders resulting from autoimmunity directed against basement membrane and/or intercellular adhesion molecules on cutaneous and mucosal surfaces. This review summarizes the limited published data evaluating dapsone
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