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Merck

E0085000

Eicosapentaenoic acid ethyl ester

European Pharmacopoeia (EP) Reference Standard

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Fórmula empírica (notación de Hill):
C22H34O2
Número CAS:
Peso molecular:
330.50
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
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Nombre del producto

Eicosapentaenoic acid ethyl ester, European Pharmacopoeia (EP) Reference Standard

SMILES string

O(CC)C(=O)\C=C\C=C\C=C\C=C\C=C\CCCCCCCCC

InChI

1S/C22H34O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24-4-2/h12-21H,3-11H2,1-2H3/b13-12+,15-14+,17-16+,19-18+,21-20+

InChI key

DTEMJWLYSQBXEL-MBFZXKRTSA-N

grade

pharmaceutical primary standard

API family

eicosapentaenoic acid

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

shipped in

wet ice

storage temp.

−20°C

Application

Eicosapentaenoic acid ethyl ester EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Christie M Ballantyne et al.
The American journal of cardiology, 110(7), 984-992 (2012-07-24)
AMR101 is an ω-3 fatty acid agent containing ≥96% pure icosapent-ethyl, the ethyl ester of eicosapentaenoic acid. The efficacy and safety of AMR101 were evaluated in this phase 3, multicenter, placebo-controlled, randomized, double-blinded, 12-week clinical trial (ANCHOR) in high-risk statin-treated
Yoshiyuki Kimura et al.
Cancer science, 96(7), 441-450 (2005-08-02)
The aim of the present work was to compare the effects of eicosapentaenoic acid (EPA) ethylester and EPA derivatives (EPAD) on tumor growth and metastasis to the lung in tumor-bearing mice. Because EPA is very unstable during long-term storage, the
Eun Young Park et al.
Journal of agricultural and food chemistry, 53(21), 8334-8341 (2005-10-13)
The effects of the addition of amino acids and peptides on the oxidation of eicosapentaenoic acid ethyl ester (EPE) encapsulated by maltodextrin (MD) were investigated. The encapsulated lipid was prepared in two steps, that is, by mixing of EPE with
Abbie L Cawood et al.
Atherosclerosis, 212(1), 252-259 (2010-06-15)
To examine n-3 polyunsaturated fatty acid (PUFA) incorporation into atherosclerotic plaques and the association with plaque inflammation and stability. Patients awaiting carotid endarterectomy (n=121) were randomised to consume control capsules or n-3 PUFA ethyl ester capsules until surgery (median 21
Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability.
Antonis Zampelas
Atherosclerosis, 212(1), 34-35 (2010-07-20)

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