N0250000

Naproxen

Name: Naproxen
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid

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About This Item

Fórmula lineal:

CH₃OC₁₀H₆CH(CH₃)CO₂H

Número CAS:

22204-53-1

Peso molecular:

230.26

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329818408

MDL number:

MFCD00010500

Beilstein/REAXYS Number:

3591068

Nombre del producto

Naproxen, European Pharmacopoeia (EP) Reference Standard

InChI key

CMWTZPSULFXXJA-VIFPVBQESA-N

SMILES string

COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O

InChI

1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1

grade

pharmaceutical primary standard

API family

naproxen

manufacturer/tradename

EDQM

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

152-154 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... PTGS1(5742), PTGS2(5743)

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Categorías relacionadas

Analytical Chromatography

Analytical Reference Materials for Pharma QC

Chromatography Standards

Pharmacopeia & Metrological Institute Standards

Biochem/physiol Actions

Inhibidor no selectivo de la ciclooxigenasa (COX-1 y COX-2).

Application

Naproxen EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

GHS08,GHS07,GHS09

signalword

Warning

hcodes

H302,H315,H319,H335,H361fd,H411

pcodes

P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number

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Separation of (R)- and (S)-naproxen using micellar chromatography and an alpha 1-acid-glycoprotein column: application for chiral monitoring in human liver microsomes by coupled-column chromatography.

D Haupt et al.

Journal of biochemical and biophysical methods, 25(4), 273-284 (1992-12-01)

A column-switching system for fast determination of (R)- and (S)-naproxen in liver microsomes has been developed. The centrifuged sample was injected directly onto a pre-column with octadecylcoated silica. The retained analytes were then directed to an alpha 1-AGP column using

Pharmacodynamic interaction of naproxen with low-dose aspirin in healthy subjects.

Marta L Capone et al.

Journal of the American College of Cardiology, 45(8), 1295-1301 (2005-04-20)

We investigated the occurrence of pharmacodynamic interaction between low-dose aspirin and naproxen. The uncertainty of cardioprotection by naproxen has encouraged its combination with aspirin in patients with arthritis and cardiovascular disease. The incubation of washed platelets with naproxen for 5

D-amino acids boost the selectivity and confer supramolecular hydrogels of a nonsteroidal anti-inflammatory drug (NSAID).

Jiayang Li et al.

Journal of the American Chemical Society, 135(2), 542-545 (2012-11-10)

As systemically used therapeutics for treating acute or chronic pains or inflammations, nonsteroidal anti-inflammatory drugs (NSAIDs) also associate with the adverse gastrointestinal and renal effects and cardiovascular risks. Thus, it is beneficial to develop topical gels that selectively inhibit cyclooxygenase-2

A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury.

Michela Campolo et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(11), 4489-4499 (2013-08-01)

Spinal cord trauma causes loss of motor function that is in part due to the ensuing inflammatory response. Hydrogen sulfide (H2S) is a potent, endogenous anti-inflammatory and neuroprotective substance that has been explored for use in the design of novel

The anti-inflammatory drugs diclofenac, naproxen and ibuprofen are found in the bile of wild fish caught downstream of a wastewater treatment plant.

Jenny-Maria Brozinski et al.

Environmental science & technology, 47(1), 342-348 (2012-11-29)

Pharmaceutical residues are ubiquitous in rivers, lakes, and at coastal waters affected by discharges from municipal wastewater treatment plants. In this study, the presence of 17 different pharmaceuticals and six different phase I metabolites was determined in the bile of

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