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Merck

N0700000

Nicotinic acid

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B3

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About This Item

Fórmula empírica (notación de Hill):
C6H5NO2
Número CAS:
59-67-6
Peso molecular:
123.11
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329818452
MDL number:
MFCD00006391
Beilstein/REAXYS Number:
109591

Nombre del producto

Nicotinic acid, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

SMILES string

OC(=O)c1cccnc1

InChI key

PVNIIMVLHYAWGP-UHFFFAOYSA-N

biological source

synthetic

grade

pharmaceutical primary standard

agency

EP

API family

nicotinic acid

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

236-239 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Application

Nicotinic acid may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

General description

Nicotinic acid is a type of vitamin B that is effective against dyslipidemia. It can also be potentially used as a peripheral vasodilator.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

379.4 °F - closed cup

flash_point_c

193 °C - closed cup

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Certificados de análisis (COA)

Lot/Batch Number

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Development and optimisation of a generic micellar electrokinetic capillary chromatography method to support analysis of a wide range of pharmaceuticals and excipients
Altria KD and McLean R
Journal of Pharmaceutical and Biomedical Analysis, 18(4-5), 807-813 (1998)
Simultaneous Estimation of Meclizine Hydrochloride and Nicotinic Acid in Pharmaceutical Dosage form by RP-HPLC Method
REDDY S, et al.
Asian Journal of Pharmaceutical Research and Health Care, 5(2) (2013)
Nicotinic acid
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 5(2), 4961-4962 (2017)
RP-HPLC method for the determination of atorvastatin calcium and nicotinic acid in combined tablet dosage form
Shah DA, et al.
Indian Journal of Pharmaceutical Sciences, 69(5), 700-700 (2007)
Janet E Digby et al.
Current opinion in lipidology, 20(4), 321-326 (2009-06-06)
Nicotinic acid is the most potent treatment clinically available for lowering LDL cholesterol and VLDL cholesterol and raising HDL cholesterol. The strong inverse relationship between coronary heart disease risk and HDL cholesterol at all levels of LDL cholesterol has, therefore
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