N5535
Nicotinamide
meets USP testing specifications
Sinónimos:
Nicotinamide, Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP
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Fórmula empírica (notación de Hill):
C6H6N2O
Número CAS:
Peso molecular:
122.12
UNSPSC Code:
12352205
NACRES:
NA.21
PubChem Substance ID:
EC Number:
202-713-4
Beilstein/REAXYS Number:
383619
MDL number:
Servicio técnico
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Permítanos ayudarlebiological source
synthetic (organic)
Quality Level
agency
USP/NF, meets USP testing specifications
assay
98.5-101.5% dry basis
form
crystals
color
white
mp
128-131 °C (lit.)
application(s)
pharmaceutical (small molecule)
SMILES string
NC(=O)c1cccnc1
InChI
1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
InChI key
DFPAKSUCGFBDDF-UHFFFAOYSA-N
Gene Information
human ... PARP1(142), SIRT2(22933)
General description
Niacinamide, also known as 3-pyridinecarboxamide, is a water soluble vitamin. It is widely present in plants, animal food and cosmetics.
Application
Niacinamide has been used:
- as a component of islet maturation culture media
- to induce differentiation of insulin secreting cells
- to compare its preclinical effectiveness with that of progesterone
Biochem/physiol Actions
Niacinamide is a primary precursor of nicotinamide adenine dinucleotide (NAD+), which is an important coenzyme in adenosine triphosphate (ATP) production. Nicotinamide deficiency is associated with pellagra.
Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Clase de almacenamiento
11 - Combustible Solids
flash_point_f
302.0 °F - closed cup
flash_point_c
150 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Necrostatin-1 supplementation enhances young porcine islet maturation and in vitro function
Lau H, et al.
Xenotransplantation (2019)
A comparison of the effects of nicotinamide and progesterone on functional recovery of cognitive behavior following cortical contusion injury in the rat
Peterson TC, et al.
Journal of Neurotrauma, 29(18), 2823-2830 (2012)
Stimulatory Role of Glycated Fetal Bovine Serum Along with Iron on In Vitro Production of Insulin by Differentiated Mouse Embryonic Stem Cells
Nishigaki I, et al.
Journal of Health Science, 57(4), 356-361 (2011)