Saltar al contenido
Merck

PHR1055

Famotidine

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

{3-[((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio]-N′-(aminosulfonyl)propaneimidamide}, N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

Acerca de este artículo

Fórmula empírica (notación de Hill):
C8H15N7O2S3
Número CAS:
76824-35-6
Peso molecular:
337.45
NACRES:
NA.24
PubChem Substance ID:
329823085
UNSPSC Code:
41116107
MDL number:
MFCD00079297

Documentos clave

Ver Toda la documentación
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarle
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarle

biological source

synthetic

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

BP, EP, USP, traceable to Ph. Eur. F0050000, traceable to USP 1269200

vapor pressure

<0.0000001 kPa ( 25 °C)

API family

famotidine

CofA

current certificate can be downloaded

storage condition

protect from light (20 mm aluminium crimp seal for unused portion)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

white to pale yellow-white

mp

325.4-327.2 °F (163—164°C)

solubility

DMF: freely soluble, acetone: practically insoluble, chloroform: practically insoluble, ethanol: practically insoluble, ether: practically insoluble, ethyl acetate: practically insoluble, glacial acetic acid: freely soluble, methanol: slightly soluble, water: very slightly soluble

application(s)

pharmaceutical (small molecule)

format

neat

shipped in

ambient

storage temp.

2-8°C

SMILES string

N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1

InChI

1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

InChI key

XUFQPHANEAPEMJ-UHFFFAOYSA-N

Gene Information

human ... HRH2(3274)

¿Está buscando productos similares? Visita Guía de comparación de productos

Categorías relacionadas

General description

Famotidine is a histamine H2-receptor antagonist, which promotes the healing of erosive esophagitis, gastric and duodenal ulcers since it inhibits the gastric acid secretion in humans.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Famotidine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using different chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

H2 histamine receptor antagonist; anti-ulcer agent

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7133 in the slot below. This is an example certificate only and may not be the lot that you receive.

Clase de almacenamiento

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

GC Determination of famotidine, ranitidine, cimetidine, and metformin in pharmaceutical preparations and serum using methylglyoxal as derivatizing reagent
Majidano AS, et al.
Chromatographia, 75(21-22), 1311-1317 (2012)
The
Profiles of Drug Substances, Excipients, and Related Methodology (2011)
Blair Kathryn Brettmann et al.
Pharmaceutical research, 30(1), 238-246 (2012-08-28)
To investigate the use of electrospinning for forming solid dispersions containing crystalline active pharmaceutical ingredients (API) and understand the relevant properties of the resulting materials. Free surface electrospinning was used to prepare nanofiber mats of poly(vinyl pyrrolidone) (PVP) and crystalline
Abolfazl Razzaghdoust et al.
The Prostate, 74(1), 41-47 (2013-09-11)
Ionizing radiation causes a series of hematological alterations especially profound lymphocytopenia during and after the radiotherapy course. To investigate whether famotidine can reduce hematologic toxicity in patients treated with radiotherapy for prostate cancer. A total of 36 patients undergoing radiotherapy
High-performance thin-layer chromatography for the determination of ranitidine hydrochloride and famotidine in pharmaceuticals.
Novakovic J.
Journal of Chromatography A, 846(1-2), 193-198 (1999)
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico