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Merck

PHR1060

Mesalamine

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

5-Aminosalicylic acid, 5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine

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Fórmula lineal:
H2NC6H3-2-(OH)CO2H
Número CAS:
89-57-6
Peso molecular:
153.14
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823090
EC Number:
201-919-1
Beilstein/REAXYS Number:
2090421
MDL number:
MFCD00007877

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InChI key

KBOPZPXVLCULAV-UHFFFAOYSA-N

InChI

1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)

SMILES string

Nc1ccc(O)c(c1)C(O)=O

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000297, traceable to USP 1392705

API family

mesalamine, mesalazine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

275-280 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... ALOX5(240), PPARG(5468), PTGS1(5742), PTGS2(5743)

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General description

Mesalamine is a drug, which is structurally similar to salicylates. It exhibits anti-inflammatory activity and is widely used as a medication for the treatment of inflammatory bowel disease, including ulcerative proctitis and Crohn′s disease.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.
Mesalamine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7173 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

flash_point_f

No data available

flash_point_c

No data available

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Spectrophotometric methods for the determination of mesalamine in bulk and pharmaceutical dosage forms
Acharjya KS, et al.
Journal of Pharmaceutical Education and Research, 1(1), 63-63 (2010)
Development and validation of UV spectrophotometric method for the determination of mesalamine in bulk and tablet formulation
Moharana KA, et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 3(2), 19-21 (2011)
Stephen J Goldie et al.
Cell death & disease, 9(11), 1072-1072 (2018-10-21)
Identifying soluble factors that influence epidermal integrity is critical for the development of preventative and therapeutic strategies for disorders such as ichthyosis, psoriasis, dermatitis and epidermal cancers. The transcription factor Grainyhead-like 3 (GRHL3) is essential for maintaining barrier integrity and
Mirjana Rajilić-Stojanović et al.
Inflammatory bowel diseases, 19(3), 481-488 (2013-02-07)
Presence of intestinal microbes is a prerequisite for the development of ulcerative colitis (UC), although deviation of the normal intestinal microbiota composition, dysbiosis, is presumably implicated in the etiology of UC. The fecal microbiota of 30 UC samples obtained from
Christian P Selinger et al.
Inflammatory bowel diseases, 19(10), 2199-2206 (2013-08-01)
Poor adherence frequently impaired the efficacy of therapy to maintain remission from inflammatory bowel diseases (IBD). There is a lack of practical and effective interventions to improve adherence. This study aimed to identify modifiable risk factors, which may yield targets
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