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Merck

PHR1128

Bupivacaine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Bupivacaine hydrochloride monohydrate, 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide

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Fórmula empírica (notación de Hill):
C18H28N2O · HCl · H2O
Número CAS:
73360-54-0
Peso molecular:
342.90
NACRES:
NA.24
PubChem Substance ID:
329823149
UNSPSC Code:
41116107
MDL number:
MFCD00941462

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Nombre del producto

Bupivacaine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C18H28N2O.ClH.H2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H;1H2

SMILES string

O.Cl.CCCCN1CCCCC1C(=O)Nc2c(C)cccc2C

InChI key

HUCIWBPMHXGLFM-UHFFFAOYSA-N

grade

certified reference material
pharmaceutical secondary standard

agency

USP 1078507
traceable to Ph. Eur. B1160000

API family

bupivacaine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Bupivacaine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry and high performance liquid chromatography methods.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Sodium channel blocker, local anesthetic.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA6762 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Development and validation of an HPLC method to determine the stability of fentanyl citrate and bupivacaine hydrochloride mixtures in infusion solutions.
Piekarski M, et al.
European Journal of Hospital Pharmacy-Science and Practice, 19(5), 447-451 (2012)
Spectrophotometric method for determination of bupivacaine hydrochloride in pharmaceutical preparations
Corciova A
European Chemical Bulletin, 2(8), 554-557 (2013)
Arnaud Chaumeron et al.
Clinical orthopaedics and related research, 471(7), 2284-2295 (2013-03-22)
The postoperative analgesic potential of periarticular anesthetic infiltration (PAI) after TKA is unclear as are the complications of continuous femoral nerve block on quadriceps function. We asked (1) whether PAI provides equal or improved postoperative pain control in comparison to
S Yayla et al.
The Veterinary record, 173(23), 580-580 (2013-10-29)
The aim of this study was to compare the effects of subarachnoid administration of hyperbaric solutions of bupivacaine or ropivacaine in xylazine-sedated calves undergoing surgery. Subarachnoid anaesthesia was performed with either 20 mg of hyperbaric bupivacaine (bupivacaine group (BG), n=10)
De Q H Tran et al.
Anesthesia and analgesia, 116(5), 1170-1175 (2013-03-16)
In this prospective, randomized, observer-blinded trial, we compared ultrasound-guided subparaneural popliteal sciatic nerve blocks performed either at or proximal to the neural bifurcation (B). We hypothesized that the total anesthesia-related time (sum of performance and onset times) would be decreased
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