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Merck

PHR1228

Dexpanthenol

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

D-Panthenol, (R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, D-Pantothenyl alcohol, Dexpanthenol, Provitamin B

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Fórmula empírica (notación de Hill):
C9H19NO4
Número CAS:
81-13-0
Peso molecular:
205.25
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823234
EC Number:
201-327-3
Beilstein/REAXYS Number:
1724947
MDL number:
MFCD00065006

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InChI key

SNPLKNRPJHDVJA-ZETCQYMHSA-N

InChI

1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)/t7-/m0/s1

SMILES string

CC(C)(CO)[C@@H](O)C(=O)NCCCO

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. D0730000, traceable to USP 1179504

API family

dexpanthenol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

density

1.20 g/mL at 20 °C (lit.)

application(s)

pharmaceutical (small molecule)
vitamins, nutraceuticals, and natural products

format

neat

storage temp.

2-30°C

Quality Level

300

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General description

Dexpanthenol is an alcohol analog of pantothenic acid and an important component of parenterals, local cosmetic preparations and multi-vitamins. It has as much biological activity as pantothenic acid and is found to be stable in aqueous solution.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Dexpanthenol may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0292 in the slot below. This is an example certificate only and may not be the lot that you receive.

Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Simultaneous determination of dexpanthenol, lidocaine hydrochloride, and mepyramine maleate in combined pharmaceutical gel by capillary electrophoresis
Akyil BG, et al.
Turkish Journal of Chemistry, 38(5), 756-764 (2014)
Development and validation of reversed phase high performance liquid chromatography method for determination of dexpanthenol in pharmaceutical formulations.
Kulikov U A and Zinchenko A A.
Journal of Pharmaceutical and Biomedical Analysis, 43(3), 983-988 (2007)
Determination of eight water-and fat-soluble vitamins in multi-vitamin pharmaceutical formulations by high-performance liquid chromatography
Moreno P and Salvado V
Journal of Chromatography A, 870(1-2), 207-215 (2000)
M Göbbels et al.
Klinische Monatsblatter fur Augenheilkunde, 209(2-3), 84-88 (1996-08-01)
In this controlled, randomized, double-masked study the effect of dexpanthenol-containing artificial tears (Siccaprotect) on patients with dry eyes was examined. 50 patients applied either dexpanthenol-containing artificial tears (Siccaprotect) or the identical, but free of dexpanthenol, eye drops five times daily
M Sachs et al.
Zeitschrift fur Ernahrungswissenschaft, 29(4), 270-283 (1990-12-01)
The aim of this study was the examination of the metabolism and mechanism of action of D-pantothenyl alcohol in patients with postoperative intestinal atony. Seven metabolically healthy patients were examined on the 4th day following colorectal surgery, before bowel activity
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