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Merck

PHR1259

Thiabendazole

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Thiabendazole, 2-(4-Thiazolyl)benzimidazole

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Fórmula empírica (notación de Hill):
C10H7N3S
Número CAS:
148-79-8
Peso molecular:
201.25
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823260
EC Number:
205-725-8
Beilstein/REAXYS Number:
611403
MDL number:
MFCD00005587

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Nombre del producto

Thiabendazole, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

WJCNZQLZVWNLKY-UHFFFAOYSA-N

InChI

1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)

SMILES string

c1ccc2[nH]c(nc2c1)-c3cscn3

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. T1410000
traceable to USP 1655000

API family

thiabendazole

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Thiabendazole may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and preparations by spectrophotometric, spectrofluorimetric and chromatography techniques.

General description

Thiabendazole is an orally effective broad spectrum anthelmintic and antimycotic drug with limited side-effects.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA9062 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Development of a spectrofluorimetric method for determination of thiabendazole in tablets
Kucukkolbasi S and Kilic E
Journal of Applied Pharmaceutical Science, 3(2), 19-19 (2013)
Mechanism of action of the fungicide thiabendazole, 2-(4?-thiazolyl) benzimidazole
Allen PM and Gottlieb D
Applied and Environmental Microbiology, 20(6), 919-926 (1970)
Determination of 81 pharmaceutical drugs by high performance liquid chromatography coupled to mass spectrometry with hybrid triple quadrupole--linear ion trap in different types of water in Serbia
Petrovic M, et al.
The Science of the Total Environment, 468(2), 415-428 (2014)
Studies on the toxicologic and pharmacologic properties of thiabendazole
Robinson HJ, et al.
Toxicology and Applied Pharmacology, 7(1), 53-63 (1965)
Suely R C Andrade et al.
Journal of pharmaceutical and biomedical analysis, 33(4), 655-665 (2003-11-19)
Three multivariate calibration methods, Principal Component Regression (PCR), the K-matrix method and Q-mode factor analysis followed by varimax and Imbrie's oblique rotations were applied to the simultaneous spectrophotometric determinations of mebendazole (MBZ)-cambendazole (CBZ) and thiabendazole (TBZ)-mebendazole in commercial samples of
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