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Merck

PHR1285

Lovastatin

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Lovastatin, Mevinolin

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About This Item

Fórmula empírica (notación de Hill):
C24H36O5
Número CAS:
75330-75-5
Peso molecular:
404.54
UNSPSC Code:
41116107
NACRES:
NA.24

Nombre del producto

Lovastatin, Pharmaceutical Secondary Standard; Certified Reference Material

SMILES string

O1[C@@H](C[C@H](CC1=O)O)CC[C@@H]2[C@H]3[C@H](C[C@H](C=C3C=C[C@@H]2C)C)OC(=O)[C@H](CC)C

InChI

1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1

InChI key

PCZOHLXUXFIOCF-BXMDZJJMSA-N

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. L0790000
traceable to USP 1370600

API family

lovastatin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

Lovastatin may find its use as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric, thermal characterization, and chromatographic techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Lovastatin, an orally administered drug, is a lactone metabolite used for the treatment of hypercholesterolemia and coronary heart diseases. It is a hexahydronaphtalene drug, belonging to the class of HMG-CoA (3-hydroxy-3-methyl-glutaryl-coenzyme A) reductase inhibitors.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3329 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Warning

Hazard Classifications

Carc. 2 - Repr. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Development and validation of a simple and fast HPLC method for determination of lovastatin, pravastatin and simvastatin
Silva TD, et al.
Journal of Chromatographic Science, 50(9), 831-838 (2012)
Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS
Downs JR, et al.
JAMA : The Journal of the American Medical Association, 279(20), 1615-1622 (1998)
Lovastatin decreases coenzyme Q levels in humans.
Folkers K, et al.
Proceedings of the National Academy of Sciences of the USA, 87(22), 8931-8934 (1990)
Colorimetric determination of simvastatin and lovastatin in pure form and in pharmaceutical formulations
El-Din Mohie MKS, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 76(3-4), 423-428 (2010)
Comparison of UV and charged aerosol detection approach in pharmaceutical analysis of statins
Novakova L, et al.
Talanta, 78(3), 834-839 (2009)
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