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Merck

PHR1423

Sodium Nitroprusside

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Sodium nitroferricyanide(III) dihydrate, Nitroprusside sodium, SNP, Sodium nitroprusside, Sodium pentacyanonitrosylferrate

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Fórmula lineal:
Na2[Fe(CN)5NO] · 2H2O
Número CAS:
13755-38-9
Peso molecular:
297.95
NACRES:
NA.24
PubChem Substance ID:
329823392
UNSPSC Code:
41116107
EC Number:
238-373-9
MDL number:
MFCD00149192

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SMILES string

[Na+].[Na+].[H]O[H].[H]O[H].O=N[Fe--](C#N)(C#N)(C#N)(C#N)C#N

InChI key

OIRZWVYIQXBRFC-UHFFFAOYSA-N

InChI

1S/5CN.Fe.NO.2Na.2H2O/c5*1-2;;1-2;;;;/h;;;;;;;;;2*1H2/q;;;;;2*-1;2*+1;;

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1614501

API family

sodium nitroprusside

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Sodium Nitroprusside is widely used as a drug to manage hypertension, via lowering elevated blood pressure by acting on the arteriolar smooth muscle.

Application

Sodium Nitroprusside may be used as a spectrophotometric reagent for the analysis of meloxicam in pharmaceutical formulations using spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7818 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Rohit Ramchandra et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(3), R271-R280 (2014-05-23)
Heart failure (HF) is associated with increased cardiac and renal sympathetic drive, which are both independent predictors of poor prognosis. A candidate mechanism for the centrally mediated sympathoexcitation in HF is reduced synthesis of the inhibitory neuromodulator nitric oxide (NO)
Gary J Hodges et al.
Experimental physiology, 99(2), 381-392 (2013-11-12)
What is the central question of this study? Previous work has produced the counterintuitive finding that the vasoconstrictor neurotransmitters noradrenaline and neuropeptide Y are involved in vasodilatation. We aimed to discover whether sympathetic neurotransmitters are required for the sustained vasodilatation
Oliver Baretella et al.
Life sciences, 118(2), 206-212 (2014-01-15)
Levels of the endothelium-derived peptide endothelin-1 (ET-1) are elevated in obese humans, and ET-1 mediated vascular tone is increased. Renal arterial smooth muscle is highly responsive to ET-1. Whether or not endothelium-derived ET-1 affects contractions of the renal artery under
Antihypertensive Drugs (1997)
Senthil Arun Kumar et al.
Marine drugs, 13(2), 788-805 (2015-02-05)
Increased seaweed consumption may be linked to the lower incidence of metabolic syndrome in eastern Asia. This study investigated the responses to two tropical green seaweeds, Ulva ohnoi (UO) and Derbesia tenuissima (DT), in a rat model of human metabolic
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