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Merck

PHR1513

Enrofloxacin

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Enrofloxacin, ENR, ENRO, Baytril

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Fórmula empírica (notación de Hill):
C19H22FN3O3
Número CAS:
93106-60-6
Peso molecular:
359.39
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823431
MDL number:
MFCD00792463
Beilstein/REAXYS Number:
5307824

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InChI

1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)

SMILES string

CCN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)C4CC4

InChI key

SPFYMRJSYKOXGV-UHFFFAOYSA-N

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001259, traceable to USP 1235900

API family

enrofloxacin

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Enrofloxacin is classified under the second generation quinolone antibiotics, known as ′fluoroquinolones′. It is a component of several medicines used to treat urinary tract infections, infections of the gastrointestinal tract, respiratory tract infections, infections of the skin structure as well as surgical prophylaxis.

Application

Enrofloxacin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and water samples by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0027 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Withdrawal time of four pharmaceutical formulations of enrofloxacin in poultry according to different maximum residues limits.
Martin SB, et al.
Journal of Veterinary Pharmacology and Therapeutics, 33(3), 246-251 (2010)
Enrofloxacin assay validation and pharmacokinetics following a single oral dose in chickens.
Da Silva RG, et al.
Journal of Veterinary Pharmacology and Therapeutics, 29(5), 365-372 (2006)
Validation of a novel HPLC sorbent material for the determination of ten quinolones in human and veterinary pharmaceutical formulations.
Samanidou VF, et al.
Journal of Separation Science, 28(18), 2444-2453 (2005)
Multi-class determination of around 50 pharmaceuticals, including 26 antibiotics, in environmental and wastewater samples by ultra-high performance liquid chromatography?tandem mass spectrometry.
Gracia-Lor E, et al.
Journal of Chromatography A, 1218(16), 2264-2275 (2011)
Jochen Springer et al.
Stroke, 45(12), 3675-3683 (2014-10-30)
Muscle wasting is a common complication accompanying stroke. Although it is known to impair poststroke recovery, the mechanisms of subacute catabolism after stroke have not been investigated in detail. The aim of this study is to investigate mechanisms of local
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