B8279
Ro-20-1724
≥98% (HPLC), solid, cAMP phosphodiesterase inhibitor
Sinónimos:
Ro 20-1724
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Fórmula empírica (notación de Hill):
C15H22N2O3
Número CAS:
Peso molecular:
278.35
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Servicio técnico
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Permítanos ayudarleNombre del producto
4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one, solid
biological source
synthetic (organic)
Quality Level
assay
≥98% (HPLC)
form
solid
solubility
ethanol: 7 mg/mL, H2O: insoluble
storage temp.
room temp
SMILES string
CCCCOc1cc(CC2CNC(=O)N2)ccc1OC
InChI
1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)
InChI key
PDMUULPVBYQBBK-UHFFFAOYSA-N
Gene Information
human ... LITAF(9516), PDE4B(5142), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
rat ... Pde4a(25638)
Application
4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one has been used:
- as a cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitor to treat cells for the determination of intracellular cAMP levels
- as a component of serum-free medium
- as phosphodiesterase inhibitor in order to study the effects of protease-activated receptor-1 (PAR-1) activation on cAMP levels
Biochem/physiol Actions
Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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