F9803

FTI-277 trifluoroacetate salt

Name: FTI-277 trifluoroacetate salt
Brand: SIGMA

≥95% (HPLC), film

Sinónimos:

N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):

C₂₂H₂₉N₃O₃S₂ · xC₂HF₃O₂

Número CAS:

170006-73-2

Peso molecular:

447.61 (free base basis)

NACRES:

NA.77

PubChem Substance ID:

329799790

UNSPSC Code:

51111800

MDL number:

MFCD06795840

Nombre del producto

FTI-277 trifluoroacetate salt, ≥95% (HPLC), film

InChI key

GJEFFRDWFVSCOJ-PXPMWPIZSA-N

SMILES string

OC(=O)C(F)(F)F.COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2ccccc2

InChI

1S/C22H29N3O3S2.C2HF3O2/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15;3-2(4,5)1(6)7/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26);(H,6,7)/t16-,20+;/m1./s1

assay

≥95% (HPLC)

form

film

storage condition

desiccated

solubility

H₂O: ≥2 mg/mL

shipped in

dry ice

storage temp.

−70°C

Quality Level

100

Categorías relacionadas

Bioactive Small Molecule Inhibitors

Application

Farnesyltransferase inhibitor 277 (FTI-277) has been used to:

inhibit protein farnesylation in breast cell lines.
in marrow-isolated adult multilineage inducible cells (MIAMI).
inhibition of farnesyl transferase in CV-1 in Origin with SV40 genes cells (COS-7).

Biochem/physiol Actions

Farnesyltransferase inhibitor 277 (FTI-277) mediates apoptosis in multiple myeloma and is regarded as a potential therapeutic agent.

Highly potent (pM/nM) Ras CAAX peptidomimetic which antagonizes both H and K-Ras oncogenic signaling. Inhibitor of farnesyltransferase (Ftase) IC₅₀= 50 nM.

Packaging

Very hygroscopic material, package in a dry room with deoxygenated MeOH and pump down the solvent. Store with desiccant.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Protective effects of farnesyltransferase inhibitor on sepsis-induced morphological aberrations of mitochondria in muscle and increased circulating mitochondrial DNA levels in mice.

Daisuke Tsuji et al.

Biochemical and biophysical research communications, 556, 93-98 (2021-04-13)

Sepsis remains a leading cause of mortality in critically ill patients and is characterized by multi-organ dysfunction. Mitochondrial damage has been proposed to be involved in the pathophysiology of sepsis. In addition to metabolic impairments resulting from mitochondrial dysfunction, mitochondrial

The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells

Bolick SCE, et al.

Leukemia, 17(2), 451-457 (2003)

Progerin expression disrupts critical adult stem cell functions involved in tissue repair

Pacheco LM, et al.

Aging (Albany. NY.), 6(12), 1049-1063 (2014)

Endothelial protective genes induced by statin is mimicked by FTI-277 and GGTI-298 drug combination-mediated ERK5 activation

Chu UB, et al.

Biochimica et Biophysica Acta, 1850(7), 1415-1425 (2015)

A chemokine regulatory loop induces cholesterol synthesis in lung-colonizing triple-negative breast cancer cells to fuel metastatic growth.

Bingchen Han et al.

Molecular therapy : the journal of the American Society of Gene Therapy, 30(2), 672-687 (2021-07-19)

Triple-negative breast cancer (TNBC) has a high propensity for organ-specific metastasis. However, the underlying mechanisms are not well understood. Here we show that the primary TNBC tumor-derived C-X-C motif chemokines 1/2/8 (CXCL1/2/8) stimulate lung-resident fibroblasts to produce the C-C motif

Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico