J4455
JSH-23
≥98% (HPLC), NF-kB nuclear translocation inhibitor, solid
Sinónimos:
4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C16H20N2
Número CAS:
Peso molecular:
240.34
UNSPSC Code:
51111800
NACRES:
NA.77
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Permítanos ayudarleNombre del producto
JSH-23, ≥98% (HPLC), solid
SMILES string
N(CCCc2ccccc2)c1c(cc(cc1)C)N
InChI
1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
InChI key
YMFNPBSZFWXMAD-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
off-white to gray-pink
solubility
DMSO: >10 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
Categorías relacionadas
Application
JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.
Biochem/physiol Actions
JSH-23 is an inhibitor of NF-kB nuclear translocation.
JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.
Other Notes
Light and air sensitive.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1B
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Kang X et al.
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