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Merck

M5449

MKT-077

≥98% (HPLC), powder

Sinónimos:

1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride, FJ-776

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About This Item

Fórmula lineal:
C21H22N3OS2Cl
Número CAS:
147366-41-4
Peso molecular:
432.00
NACRES:
NA.77
PubChem Substance ID:
329818014
UNSPSC Code:
12352200
MDL number:
MFCD27665468

Nombre del producto

MKT-077, ≥98% (HPLC), powder

InChI key

VSKYOTRJSLYFHX-UXJRWBAGSA-M

SMILES string

CN(C1=C(S/2)C=CC=C1)C2=C3C(N(CC)/C(S\3)=C/C4=[N+](CC)C=CC=C4)=O.[Cl-]

InChI

1S/C21H22N3OS2.ClH/c1-4-23-13-9-8-10-15(23)14-18-24(5-2)20(25)19(27-18)21-22(3)16-11-6-7-12-17(16)26-21;/h6-14H,4-5H2,1-3H3;1H/q+1;/p-1/b21-19+;

assay

≥98% (HPLC)

form

powder

color

orange to red

solubility

H2O: 10 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Categorías relacionadas

Biochem/physiol Actions

MKT-077 is an inhibitor of mitochondrial hsp70 family member, mortalin (mot-2)n
MKT-077 is an inhibitor of mitochondrial hsp70 family member, mortalin (mot-2)n; causes selective death of cancer cells.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000158221
0000158220
0000158221
0000123026

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PloS one, 12(2), e0170470-e0170470 (2017-02-09)
Myelodysplastic syndromes (MDS) are the most common adult myeloid blood cancers in the US. Patients have increased apoptosis in their bone marrow cells leading to low peripheral blood counts. The full complement of gene mutations that contribute to increased apoptosis
Victoria J Gennaro et al.
BMC cancer, 19(1), 258-258 (2019-03-25)
The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that functions as a critical determinant of this cell fate
Jemma Day et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(12), 14611-14624 (2019-11-07)
Plasmodium falciparum is the most lethal of human-infective malaria parasites. A hallmark of P. falciparum malaria is extensive remodeling of host erythrocytes by the parasite, which facilitates the development of virulence properties such as host cell adhesion to the endothelial
Sunil Joseph et al.
Biology open, 6(4), 481-488 (2017-03-16)
Earlier studies suggested that
Ahmed Edan Dhamad et al.
American journal of physiology. Cell physiology, 318(2), C289-C303 (2019-12-05)
Glucose-regulated protein 75 (GRP75) was first characterized in mammals as a heat shock protein-70 (HSP70) family stress chaperone based on its sequence homology. Extensive studies in mammals showed that GRP75 is induced by various stressors such as glucose deprivation, oxidative
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