P0037
PP242 hydrate
≥98% (HPLC), powder
Sinónimos:
2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C16H16N6O · xH2O
Número CAS:
Peso molecular:
308.34 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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InChI
1S/C16H16N6O.H2O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12;/h3-8,20,23H,1-2H3,(H2,17,18,19);1H2
SMILES string
O.CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c4c(N)ncnc14
InChI key
FMDOLJSFPXFBIL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
Categorías relacionadas
Application
PP242 hydrate has been used:
- as a mammalian target of rapamycin (mTOR) inhibitor to study its effects on rat fibroblast mTOR complex 1 and 2 (mTORC1 & 2) signaling
- as an mTOR inhibitor to treat mouse embryonic fibroblasts (MEF) and cumulus cells (CCs) to study its effects on reactivation of embryonic nucleoli and ribosome biogenesis
- as a target of rapamycin (TOR) kinase inhibitor for the treatment of Arabidopsis to study its effects against Fusarium graminearum infection
Biochem/physiol Actions
PP242 is a potent and selective mTOR inhibitor.
PP242 is a potent and selective mTOR inhibitor. PP242 is a first selective inhibitor that targets ATP domain of mTOR.
Features and Benefits
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Transient inhibition of rDNA transcription in donor cells improves ribosome biogenesis and preimplantation development of embryos derived from somatic cell nuclear transfer
Liao C, et al.
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TOR signaling downregulation increases resistance to the cereal killer Fusarium graminearum
Aznar N, et al.
Plant signaling & behavior, 13(2), e1414120-e1414120 (2018)
Eleftherios Karanasios et al.
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Plant signaling & behavior, 13(2), e1414120-e1414120 (2017-12-12)
TOR is the master regulator of growth and development that senses energy availability. Biotic stress perturbs metabolic and energy homeostasis, making TOR a good candidate to participate in the plant response. Fusarium graminearum (Fusarium) produces important losses in many crops
Min Liu et al.
Biochemical and biophysical research communications, 463(3), 255-261 (2015-05-24)
Activation of quiescent hepatic stellate cells (HSCs) is the central event of liver fibrosis. The translational machinery is an optimized molecular network that affects cellular homoeostasis and diseases, whereas the role of protein translation in HSCs activation and liver fibrosis
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