P3510
Papaverine hydrochloride
≥98% (titration by HCL04), powder, cerebral vasodilator
Sinónimos:
6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride
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Fórmula empírica (notación de Hill):
C20H21NO4 · HCl
Número CAS:
Peso molecular:
375.85
MDL number:
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
200-502-1
Beilstein/REAXYS Number:
3921435
Servicio técnico
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Permítanos ayudarleNombre del producto
Papaverine hydrochloride, powder
assay
≥98%
Quality Level
form
powder
color
white
solubility
H2O: 25 mg/mL
SMILES string
COC1=C(OC)C=C(C(CC2=CC(OC)=C(OC)C=C2)=NC=C3)C3=C1.Cl
InChI
1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H
InChI key
UOTMYNBWXDUBNX-UHFFFAOYSA-N
Gene Information
human ... PDE4B(5142)
General description
Papaverine hydrochloride belongs to the group of benzylisoquinoline alkaloid. It is obtained from opium poppy.
Application
Papaverine hydrochloride has been used:
- in oxygenated Krebs solution for tissue mechanics analysis
- as a vasodilator in heparinized horse serum in tissue uptake technique
- as an inhibitor of H-MPP+ uptake into stably transfected 293 cells expressing either extraneuronal monoamine transporter (EMT) human or EMT rat
Biochem/physiol Actions
Papaverine is originally used to resolve male impotence.
Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage
Liu James K and Couldwell William T
Neurocritical Care, 2(2), 124-132 (2005)
Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells
Grundemann D, et al.
British Journal of Pharmacology, 137(6), 910-918 (2002)
Increased glomerular albumin permeability in old spontaneously hypertensive rats
Bakoush O, et al.
Nephrology, Dialysis, and Transplantation, 19(7), 1724-1731 (2004)