P4498

Pravastatin sodium salt hydrate

Name: Pravastatin sodium salt hydrate
Brand: SIGMA

synthetic (organic), ≥98% (HPLC), HMG-CoA reductase inhibitor, powder

Sinónimos:

(βR, δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β, δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic acid sodium hydrate, Eptastatin sodium salt hydrate

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About This Item

Fórmula empírica (notación de Hill):

C₂₃H₃₅O₇Na · xH₂O

Número CAS:

81131-70-6

Peso molecular:

446.51 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

329820206

NACRES:

NA.77

MDL number:

MFCD00887601

Nombre del producto

Pravastatin sodium salt hydrate, ≥98% (HPLC), powder

SMILES string

[Na+].[H][C@@](O)(CC[C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@H](OC(=O)[C@@H](C)CC)[C@]12[H])C[C@@H](O)CC([O-])=O

InChI key

VWBQYTRBTXKKOG-IYNICTALSA-M

InChI

1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1

biological source

synthetic (organic)

assay

≥98% (HPLC)

form

powder

color

white

mp

171.2-173 °C

solubility

H₂O: >10 mg/mL

originator

Bristol-Myers Squibb

storage temp.

2-8°C

Application

Pravastatin sodium salt hydrate has been used in the enzymatic method to measure mevalonic acid in serum.

Biochem/physiol Actions

Competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Inhibits cholesterol synthesis in vivo (Ki ~1 nM).

Pravastatin sodium is a competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Pravastatin sodium is an orally effective hypocholesterolaemic agent which is structurally similar to lovastatin and compactin.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Cost-effectiveness of statins for primary cardiovascular prevention in chronic kidney disease.

Kevin F Erickson et al.

Journal of the American College of Cardiology, 61(12), 1250-1258 (2013-03-19)

The authors sought to evaluate the cost-effectiveness of statins for primary prevention of myocardial infarction (MI) and stroke in patients with chronic kidney disease (CKD). Patients with CKD have an elevated risk of MI and stroke. Although HMG Co-A reductase

Disposition of pravastatin sodium, a tissue-selective HMG-CoA reductase inhibitor, in healthy subjects.

S M Singhvi et al.

British journal of clinical pharmacology, 29(2), 239-243 (1990-02-01)

Pravastatin sodium, a competitive inhibitor of HMG-CoA reductase, is a new orally effective hypocholesterolaemic agent. In a two-way crossover study, eight healthy male subjects each received an intravenous and an oral dose of [14C]-pravastatin sodium. The oral absorption of [14C]

Statins for treating stable angina: can statins improve the plaque morphology and angina?

Cheol Whan Lee et al.

Future cardiology, 9(2), 155-158 (2013-03-08)

[Dermatomyositis].

Sylvain Glitho et al.

La Revue du praticien, 63(5), 626-626 (2013-06-26)

Drug development for progeria yields insights into normal aging.

Kevin Jiang

Nature medicine, 19(5), 515-515 (2013-05-09)

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