SML0837
FAK Inhibitor 14
≥95% (HPLC)
Sinónimos:
1,2,4,5-Benzene tetraamine tetrahydrochloride, 1,2,4,5-Benzenetetraamine 4HCl, 1,2,4,5-Benzenetetraamine tetrahydrochloride, Benzene-1,2,4,5-tetramine tetrahydrochloride, NSC 667249, Y15
Iniciar sesión para ver los precios por organización y contrato.
Seleccione un Tamaño
About This Item
Fórmula empírica (notación de Hill):
C6H10N4 · 4HCl
Número CAS:
Peso molecular:
284.01
UNSPSC Code:
12352200
EC Number:
224-822-6
NACRES:
NA.77
Nombre del producto
FAK Inhibitor 14, ≥95% (HPLC)
SMILES string
[Cl-].[Cl-].[Cl-].[Cl-].Nc1c(cc(c(c1)N)N)N.[H+].[H+].[H+].[H+]
InChI key
BZDGCIJWPWHAOF-UHFFFAOYSA-N
InChI
1S/C6H10N4.4ClH/c7-3-1-4(8)6(10)2-5(3)9;;;;/h1-2H,7-10H2;4*1H
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
, faint purple to dark brown
solubility
H2O: 20 mg/mL, clear
storage temp.
room temp
Quality Level
Categorías relacionadas
Application
FAK Inhibitor 14 has been used in the metastasis assay. It is also used to study its effect on bone morphogenetic protein 7 (BMP-7)-induced cell crawling and adhesion.
Biochem/physiol Actions
1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14; Y15) is a cell-permeable, selective focal adhesion kinase (FAK) inhibitor.
1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14; Y15) is a cell-permeable, selective focal adhesion kinase (FAK) inhibitor. Focal adhesion kinase (FAK) is essential in regulating integrin signaling pathways responsible for cell survival, cell proliferation and motility. Phosphorylation of FAK tyrosine 397 (Y397) forms a high affinity binding site for the SH2 domain of the Src family kinases and PI3 kinase. FAK is overexpressed in a number of human tumors. 1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14, Y15) blocks phosphorylation of Y397-FAK, which results in neuroblastoma cell detachment and apoptosis.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Fak page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Elija entre una de las versiones más recientes:
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
T A Sovershaev et al.
Thrombosis research, 147, 24-31 (2016-09-27)
Bone morphogenetic protein (BMP) 7 is abundant in atherosclerotic plaques and increases monocyte pro-coagulant activity by enhancing tissue factor (TF) expression. While several members of the BMP superfamily are able to serve as chemotactic agents for monocytes, the role of
Erna-Zulaikha Dayang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 133, 111073-111073 (2021-01-01)
Sepsis is a life-threatening condition often leading to multiple organ failure for which currently no pharmacological treatment is available. Endothelial cells (EC) are among the first cells to respond to pathogens and inflammatory mediators in sepsis and might be a
Sophie Bachy et al.
iScience, 25(2), 103758-103758 (2022-02-12)
Macrophages play an important role in immune and matrix regulation during pancreatic adenocarcinoma (PDAC). Collagen deposition massively contributes to the physical and functional changes of the tissue during pathogenesis. We investigated the impact of thick collagen fibers on the phenotype
Xiaoling Wang et al.
International journal of molecular sciences, 22(18) (2021-09-29)
By employing an innovative biohybrid membrane, the present study aimed at elucidating the mechanistic role of the focal adhesion kinase (FAK) in epithelial morphogenesis in vitro over 4, 7, and 10 days. The consequences of siRNA-mediated FAK knockdown on epithelial
The adhesion g-Protein-coupled receptor, gPr56/aDgrg1, inhibits cell?extracellular Matrix signaling to Prevent Metastatic Melanoma growth.
Millar M W, et al.
Frontiers in Oncology, 8, 8-8 (2018)
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico