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W1628

Wortmannin

Name: Wortmannin
Brand: SIGMA

From Penicillium funiculosum, ≥98% (HPLC and TLC), phosphatidylinositol 3-kinase inhibitor, powder

Sinónimos:

KY 12420

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Fórmula empírica (notación de Hill):

C₂₃H₂₄O₈

Número CAS:

19545-26-7

Peso molecular:

428.43

NACRES:

NA.77

PubChem Substance ID:

24278777

UNSPSC Code:

12352207

MDL number:

MFCD00133927

Beilstein/REAXYS Number:

67676

Assay:

≥98% (HPLC and TLC)

Form:

powder

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Propiedades

Nombre del producto

Wortmannin, from Penicillium funiculosum, ≥98% (HPLC and TLC)

biological source

Penicillium funiculosum

Quality Segment

300

assay

≥98% (HPLC and TLC)

form

powder

color

off-white

solubility

DMSO: soluble, H₂O: unstable

storage temp.

2-8°C

SMILES string

[H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C3=C2C(=O)c4occ5C(=O)O[C@H](COC)[C@@]3(C)c45

InChI

1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1

InChI key

QDLHCMPXEPAAMD-QAIWCSMKSA-N

Gene Information

human ... PIK3CD(5293), PIK3CG(5294), PIK3R1(5295)

Descripción

Biochem/physiol Actions

Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC₅₀ of 2-4 nM.

Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC₅₀ of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.