1019701

USP

Amiloride hydrochloride

Name: Amiloride hydrochloride
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

Amiloride hydrochloride dihydrate, N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate

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About This Item

Fórmula empírica (notación de Hill):

C₆H₈ClN₇O · HCl · 2H₂O

Número CAS:

17440-83-4

Peso molecular:

302.12

MDL number:

MFCD11046655

UNSPSC Code:

41116107

NACRES:

NA.24

Nombre del producto

Amiloride hydrochloride, United States Pharmacopeia (USP) Reference Standard

SMILES string

Clc1nc(c(nc1N)N)C(=O)N\C(=N\[H])\N.Cl.O.O

InChI

1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2

InChI key

LTKVFMLMEYCWMK-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

amiloride

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

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Categorías relacionadas

Analytical Reference Materials for Pharma QC

Pharmacopeia & Metrological Institute Standards

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Application

Amiloride hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Amiloride Hydrochloride and Hydrochlorothiazide Tablets
Amiloride Hydrochloride Tablets

General description

Amiloride hydrochloride is a photosensitive yellow powder used as a mild diuretic drug.

Other Notes

Sales restrictions may apply.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Effect of apical hyperosmotic sodium challenge and amiloride on sodium transport in human bronchial epithelial cells from cystic fibrosis donors.

Hector Rasgado-Flores et al.

American journal of physiology. Cell physiology, 305(11), C1114-C1122 (2013-08-30)

Hypertonic saline (HS) inhalation therapy benefits cystic fibrosis (CF) patients [Donaldson SH, Bennet WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. N Engl J Med 354: 241-250, 2006; Elkins MR, Robinson M, Rose BR, Harbour C, Moriarty CP, Marks

Novel small molecule epithelial sodium channel inhibitors as potential therapeutics in cystic fibrosis - a patent evaluation.

Matthias Schoenberger et al.

Expert opinion on therapeutic patents, 23(10), 1383-1389 (2013-08-21)

Novel molecular platforms for epithelial sodium channel (ENaC) modulators are claimed in the following six patents: WO2012035158(A1); WO2009074575(A2); WO2011028740(A1); WO2009150137(A2); WO2011079087(A1); WO2008135557(A1). These ENaC inhibitors may be used in blocking transepithelial sodium and consequently water absorption across airway epithelia. This

The Na⁺/H⁺ exchanger isoform 3 is required for active paracellular and transcellular Ca²⁺ transport across murine cecum.

Juraj Rievaj et al.

American journal of physiology. Gastrointestinal and liver physiology, 305(4), G303-G313 (2013-06-15)

Intestinal calcium (Ca²⁺) absorption occurs via paracellular and transcellular pathways. Although the transcellular route has been extensively studied, mechanisms mediating paracellular absorption are largely unexplored. Unlike passive diffusion, secondarily active paracellular Ca²⁺ uptake occurs against an electrochemical gradient with water

Na+/H+ and Na+/NH+4 activities of zebrafish NHE3b expressed in Xenopus oocytes.

Yusuke Ito et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 306(5), R315-R327 (2014-01-10)

Zebrafish Na(+)/H(+) exchanger 3b (zNHE3b) is highly expressed in the apical membrane of ionocytes where Na(+) is absorbed from ion-poor fresh water against a concentration gradient. Much in vivo data indicated that zNHE3b is involved in Na(+) absorption but not

Acute inhibition of NCC does not activate distal electrogenic Na+ reabsorption or kaliuresis.

Robert W Hunter et al.

American journal of physiology. Renal physiology, 306(4), F457-F467 (2014-01-10)

Na(+) reabsorption from the distal renal tubule involves electroneutral and electrogenic pathways, with the latter promoting K(+) excretion. The relative activities of these two pathways are tightly controlled, participating in the minute-to-minute regulation of systemic K(+) balance. The pathways are

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