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SCC115 CH27 Mouse B Cell Lymphoma Cell Line

CH27 mouse B cell lymphoma celll line is a useful model for the study of B-cell biology and tumor immunology.

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SCC115
≥1X10⁶ cells/vial  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC115
      DescriptionCH27 Mouse B Cell Lymphoma Cell Line
      OverviewCH27 Mouse B Cell Lymphoma Cell Line is one of the CH series of mouse B-cell lymphomas that arise from the spleen cells of B10.H-2a-H-4b p/Wts (2a4b) mice, either spontaneously or after transplantation of the spleen cells to syngeneic or F1 hybrid recipients (1, 2, 3).

      CH27 cells express surface IgM and Ia antigens (3) along with Ly-1 (CD5) and Ig which bind sheep (SRBC) and chicken erythrocytes and bromelain-treated mouse erythrocytes (2, 3, 4). The hapten recognized by SRBC-binding CH lymphomas is a phospholipid, either phosphatidylchone or sphingomyelin (5). Phospholipids are a common component of cell membranes and thus cells expressing immunoglobulin with specificity for SRBC can also be found in the spleens of normal mice (7). This suggests that CH lymphomas represent neoplastic analogues of Ly-1+ normal B-cells (3).

      References
      1. Lanier LL, et al. (1982) Transplantable B-cell lymphomas in B10.H-2aH-4b p/Wts mice. Immunogenetics 16(4): 367-371.
      2. Bishop GA, Haughton G (1985) Use of the CH lymphomas as models of murine B cell differentiation. Immunol Res 5(4): 263-70.
      3. Haughton G, et al. (1986) The CH series of murine B cell lymphomas: neoplastic analogues of Ly-1+ normal B cells. Immunol Rev 93: 35-51.
      4. Pennell CA, et al. (1985) Cross-reactive idiotypes and common antigen binding specificities expressed by a series of murine B-cell lymphomas: etiological implications. Proc Natl Acad Sci USA 82: 3799-3803.
      5. Mercolino TJ, et al. (1986) Phosphatidyl choline is recognized by a series of Ly-1+ murine B cell lymphomas specific for erythrocyte membranes. J Exp Med 163: 155-165.
      6. Pennell CA, et al. (1988) Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas. J Immunol 141(8): 2788 - 2296.
      7. Bishop GA, Haughton G (1985) H-2 control of expression of an idiotype shared by normal B cells and a B-cell lymphoma. Immunogenetics 21: 355-366.
      Alternate Names
      • CH27 [Mouse lymphoma]
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationCH27 mouse B cell lymphoma celll line is a useful model for the study of B-cell biology and tumor immunology.
      Application NotesThis product is intended for sale and sold solely for internal non-commercial research use per the terms of the “Restricted Use Agreement” as detailed in the product documentation. For information regarding any other uses, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X106 viable cells.
      • Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC115 04054839406690

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