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SCC253 WB-F344 Rat Liver Progenitor Cell Line

The WB-F344 cell line is a well-established and versatile model for studies of liver cell renewal, differentiation, and origination of hepatic cancers.

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SCC253
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC253
      DescriptionWB-F344 Rat Liver Progenitor Cell Line
      Overview"Among adult organs, the liver has the unique ability to regenerate after injury, a feature that has generated a high level of interest in liver progenitor cells for therapeutic uses. Liver progenitor cells (also known as oval cells) have potential to differentiate into either of the two epithelial cell types in the liver, biliary epithelial cells or hepatocytes.1 The inherent versatility and clinical applicability of liver progenitor cells highlight the importance of cellular models for this cell type.
      WB-F344 is a highly cited, spontaneously immortalized rat liver progenitor cell line. WB-F344 cells are derived from adult tissue yet have the characteristic phenotype of oval cells and proliferate rapidly.3 WB-F344 cells express markers of liver progenitor cells, including EpCAM, Thy1, and α-fetoprotein.3 WB-F344 cells are non-tumorigenic, but can undergo neoplastic transformation both in response to treatment with carcinogenic agents4 and spontaneously when maintained in a post-confluent state.5 The WB-F344 cell line is a well-established and versatile model for studies of liver cell renewal, differentiation, and origination of hepatic cancers.

      Source
      WB-F344 rat liver progenitor cell line was isolated from the liver epithelium of an adult Fischer-344 rat.2

      References
      1. Int J Exp Pathol 2005, 86(1): 1-18.
      2. Stem Cells Cloning 2010, 3: 39-47.
      3. Exp Cell Res 1984, 154(1): 38-52.
      4. Am J Pathol 1989, 135(1): 63-71.
      5. Am J Pathol 1998, 153(6): 1913-1921.
      Background InformationAmong adult organs, the liver has the unique ability to regenerate after injury, a feature that has generated a high level of interest in liver progenitor cells for therapeutic uses. Liver progenitor cells (also known as oval cells) have potential to differentiate into either of the two epithelial cell types in the liver, biliary epithelial cells or hepatocytes.1 The inherent versatility and clinical applicability of liver progenitor cells highlight the importance of cellular models for this cell type.
      WB-F344 is a highly cited, spontaneously immortalized rat liver progenitor cell line. WB-F344 cells are derived from adult tissue yet have the characteristic phenotype of oval cells and proliferate rapidly.3 WB-F344 cells express markers of liver progenitor cells, including EpCAM, Thy1, and α-fetoprotein.3 WB-F344 cells are non-tumorigenic, but can undergo neoplastic transformation both in response to treatment with carcinogenic agents4 and spontaneously when maintained in a post-confluent state.5 The WB-F344 cell line is a well-established and versatile model for studies of liver cell renewal, differentiation, and origination of hepatic cancers.

      Source
      WB-F344 rat liver progenitor cell line was isolated from the liver epithelium of an adult Fischer-344 rat.2

      References
      1. Int J Exp Pathol 2005, 86(1): 1-18.
      2. Stem Cells Cloning 2010, 3: 39-47.
      3. Exp Cell Res 1984, 154(1): 38-52.
      4. Am J Pathol 1989, 135(1): 63-71.
      5. Am J Pathol 1998, 153(6): 1913-1921.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationThe WB-F344 cell line is a well-established and versatile model for studies of liver cell renewal, differentiation, and origination of hepatic cancers.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Hepatocyte Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X106 viable cells.
      • Cells are tested negative for infectious diseases by a Mouse/Rat Comprehensive CLEAR Panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of rat origin and negative for inter-species contamination from mouse, human, chinese hamster, Golden Syrian hamster, and Non-human Primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
      • Cells are negative for mycoplasma contamination.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe cells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC253 04065266920109