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SCC442 HPDE6c7 Human Pancreatic Duct Epithelial Cell Line

HPDE6c7 cells are a versatile model for the pancreatic ductal epithelium, facilitating the development of strategies for the chemoprevention of human pancreatic cancers.

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SCC442
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC442
      DescriptionHPDE6c7 Human Pancreatic Duct Epithelial Cell Line
      Alternate Names
      • HPDE6-C7
      • H6c7
      • H6C7
      • HPDEC
      Background InformationPancreatic cancer is the fourth commonest cause of cancer death in North America and has one of the worst prognoses. Greater than 90% of these tumors arise from the pancreatic duct epithelium.1 Even when the primary tumor is small and localized, the prognosis remains poor and chemotherapy or radiotherapy has demonstrated limited effectiveness.2 The availability of dynamic models remains crucial to the study and understanding of the biological significance of the genetic changes underlying pancreatic cancer, especially in the context of pancreatic duct epithelial cell carcinogenesis.
      The immortalized HPDE6c7 cell line demonstrates a near normal genotype and phenotype of pancreatic duct epithelial cells.3 HPDE6c7 cells retain normal Ki-ras, p53, C-myc, and p16INK4A genotypes but lack the p53 functional pathway.3 The HPDE6c7 cell line is useful for studies on the molecular basis of pancreatic duct cell carcinogenesis and islet cell differentiation. HPDE6c7 cells are a versatile model for the pancreatic ductal epithelium, facilitating the development of strategies for the chemoprevention of human pancreatic cancers.

      Source
      HPDE6c7 cells originated from normal human pancreatic duct of a 63-year-old female, having been genotypically altered by infection with retrovirus vector expressing E6E7 genes of human papilloma virus (HPV)-16.3


      References
      1. Am J Pathol 1996, 148(6): 1763-1770.
      2. Am J Pathol 1998, 153(1): 263-269.
      3. Am J Pathol 2000, 157(5): 1623-1631.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationHPDE6c7 cells are a versatile model for the pancreatic ductal epithelium, facilitating the development of strategies for the chemoprevention of human pancreatic cancers.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Epithelial Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X106 viable cells.
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR Panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and Non-human Primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
      • Cells are negative for mycoplasma contamination.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      • This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck to request certain information about you and the establishment where the GMOs are being handled. Click here for Enduser Declaration (EUD) Form.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC442 04065266067057