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852110 Fmoc-(Dmb)Gly-OH

Fmoc-(Dmb)Gly-OH Novabiochem®. CAS 166881-42-1, molar mass 447.48 g/mol.

Fmoc-(Dmb)Gly-OH MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 166881-42-1 Molar Mass: 447.48 g/mol Hill Formula: C₂₆H₂₅NO₆
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
166881-42-1C₂₆H₂₅NO₆447.48 g/mol
Description
Catalogue Number852110
Replaces04-12-1268
Brand Family Novabiochem®
Alternate Names
  • N-α-Fmoc-N-α-(2, 4-dimethoxybenzyl)-glycine
Background InformationFmoc-(Dmb)Gly-OH is an excellent reagent for enhancing synthetic efficiency of glycine-containing peptides.

Like the analogous Hmb derivative Fmoc-(FmocHmb)Gly-OH, the use of this derivative prevents aggregation during chain assemby, thereby leading to faster and more predictable acylation and deprotection reactions. Furthermore, it can prevent aspartimide formation when used to introduce a Gly immediately before an Asp residue and help promote cyclization of Gly-containing peptides [1].

The analogous (Tmob)Gly derivative has been used by Bayer and colleagues to prepare a 64-residue transmembrane peptide in remarkable purity [2].

The product number for this product was previously 04-12-1268.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
References
Product Information
CAS number166881-42-1
Hill FormulaC₂₆H₂₅NO₆
Molar Mass447.48 g/mol
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationFmoc-(Dmb)Gly-OH Novabiochem®. CAS 166881-42-1, molar mass 447.48 g/mol.
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Storage class10 - 13 Other liquids and solids
WGKWGK 3 highly hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at -15°C to -25°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Color (visual)white to slight yellow to beige
Appearance of substance (visual)powder
Identity (IR)passes test
Purity (TLC(157B))≥ 98 %
Assay (HPLC, area%)≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF)passes test
Assay (acidimetric)≥ 94.0 %
Water (K. F.)≤ 1.00 %
For TLC-Systems see our General Catalog

Documentation

Fmoc-(Dmb)Gly-OH SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] M. El Haddadi, et al. (2000) J. Pept. Sci., 6, 560 (2000) J. Pept. Sci., 6, 560.
  • [2] K. Jauch, et al. in "Peptides 1996: Proc. 24th European Peptide Symposium", R. Ramage and R. Epton (Eds), Mayflower Scientific Ltd., 1996, pp 497.