96 well Template Single
- Document Type:
- Technical Information
ezhs40mm
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96 well Template 2 Up
- Document Type:
- Technical Information
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Protocol- EZHS40
- Document Type:
- Protocols
- Product Catalog Number:
- EZHS40
- Product Catalog Name:
- High Sensitivity Human Amyloid β40 ELISA
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Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease.
- Noradrenergic deficits have been described in the hippocampus and the frontal cortex of Alzheimer's disease brains, which are secondary to locus coeruleus degeneration. Locus coeruleus is the brain stem nucleus responsible for synthesis of noradrenaline and from where all noradrenergic neurons project. In addition, it has been suggested that noradrenaline might play a role in modulating inflammatory responses in Alzheimer's disease. In this study we aimed to investigate the effect of various agonists and antagonists for adrenergic receptors on amyloid precursor protein processing. Among them, we found that prazosin, an α(1)-adrenoceptor antagonist, was able to reduce the generation of amyloid β in N2a cells. Treatment of transgenic APP23 mice with prazosin prevented memory deficits over time. Although prazosin did not influence amyloid plaque load, it induced astrocytic proliferation and increased the release of apolipoprotein E and anti-inflammatory cytokines. These findings suggest that chronic treatment with prazosin leads to an anti-inflammatory response with potential beneficial effects on cognitive performance.
- Document Type:
- Reference
- Product Catalog Number:
- Multiple
- Product Catalog Name:
- Multiple
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Quality Control Range Sheet- 0QC-114R and 0QC-214R
- Document Type:
- Technical Information
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Quality Control Ranges: High Sensitivity Human Amyloid
- Document Type:
- Technical Information