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851087 PyClock

PyClock 6-Chloro-benzotriazole-1-yloxy-tris-pyrrolidinophosphonium hexafluorophosphate Novabiochem®. CAS 893413-42-8, molar mass 554.84 g/mol.

PyClock MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 893413-42-8 Molar Mass: 544.8 g/mol Hill Formula: C₁₈H₂₇ClF₆N₆OP₂
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851087
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
893413-42-8C₁₈H₂₇ClF₆N₆OP₂544.8 g/mol
Description
Catalogue Number851087
Brand Family Novabiochem®
Alternate Names
  • 6-Chloro-benzotriazole-1-yloxy-tris-pyrrolidinophosphonium hexafluorophosphate
Background InformationPyClocK is the 6-chloro analog of PyBOP. Reaction of protected amino acids with PyClocK in the presence of base generates the corresponding 6-chloro-1-benzotriazolyl (Cl-OBt) ester. These active esters are considerably more reactive than those produced when using PyBOP or HBTU, owing to 6-chloro-1-hydroxybenzotriazole (Cl-HOBt) being more acidic than HOBt.

PyClocK is an excellent coupling reagent for situations where carboxyl activation may be sluggish, such as cyclizations and fragment condensations, as unlike imminium-based reagents such as HBTU and HATU excess PyClocK cannot cause end-capping of peptide chains.
References
Product Information
CAS number893413-42-8
Hill FormulaC₁₈H₂₇ClF₆N₆OP₂
Molar Mass544.8 g/mol
Quality LevelMQ200
Applications
ApplicationPyClock 6-Chloro-benzotriazole-1-yloxy-tris-pyrrolidinophosphonium hexafluorophosphate Novabiochem®. CAS 893413-42-8, molar mass 554.84 g/mol.
Biological Information
Physicochemical Information
Melting Point174 - 180 °C
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Hazard Pictogram(s) Hazard Pictogram(s)
Hazard Statement(s)H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary Statement(s)P261: Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264: Wash skin thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/ eye protection/ face protection.
P302 + P352: IF ON SKIN: Wash with plenty of water.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Signal WordWarning
Storage class10 - 13 Other liquids and solids
WGKWGK 3 highly hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at +2°C to +8°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Color (visual)white to slight yellow to beige
Appearance of substance (visual)powder
Identity (IR)conforms
Assay (HPLC, area%)≥ 98.0 % (a/a)
Solubility (5% in NMP (1-Methyl-2-pyrrolidone))clear